PMID: 8946279Nov 1, 1996Paper

Antiplatelet glycoprotein autoantibodies in patients with autoimmune diseases with and without thrombocytopenia

Journal of Clinical Immunology
I CordianoF Fabris

Abstract

The presence and specificity of antiplatelet autoantibodies in 32 patients with primary and 18 patients with secondary autoimmune thrombocytopenic purpura (AITP), as well as 11 non-thrombocytopenic patients with systemic autoimmune diseases, were studied. By means of the direct and indirect monoclonal antibody immobilization of platelet antigen (MAIPA) assay, antiplatelet autoantibodies were detected using monoclonal antibodies specific for platelet glycoproteins (GPs) Ib, IIb/IIIa, Ia/IIa, and IV. Serum antiplatelet autoantibodies were found in 18 of 32 primary AITP patients (56%), 6 of 18 secondary AITP patients (33%), and 5 of 11 nonthrombocytopenic patients (45%). Platelet-associated autoantibodies were detected in five of eight patients with primary (62%) and in four of eight patients with secondary AITP (50%) and in two of four patients without thrombocytopenia (50%). Multiple antibody reactivity, mainly against GPs IIb/IIIa and Ib and, in a few patients, against Ia/IIa, was found. Using MAIPA, platelet xylene eluates from 20 patients were also studied. Antiplatelet elutable autoantibodies were related to thrombocytopenia; autoantibodies against membrane GPs Ib and IIb/IIIa were demonstrable in 84 and 63% of eluates from ...Continue Reading

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Citations

Sep 16, 1998·Clinical and Experimental Immunology·I CordianoF Fabris
Mar 6, 2003·Vox Sanguinis·Michael P Reilly, Steven E McKenzie
Oct 6, 2004·British Journal of Haematology·Eleni TholouliMichael Makris
Mar 8, 2006·European Journal of Haematology·Mohsen HamidpourNigel Lindsey
Jan 31, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Subbiah ThangaduraiYerramilli Anjaneyulu
Dec 25, 2007·The Korean journal of laboratory medicine·Hyunjong KimKyungja Han

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