Antiplatelet therapy duration following bare metal or drug-eluting coronary stents: the dual antiplatelet therapy randomized clinical trial

JAMA : the Journal of the American Medical Association
Dean J KereiakesDual Antiplatelet Therapy (DAPT) Study Investigators

Abstract

Despite antirestenotic efficacy of coronary drug-eluting stents (DES) compared with bare metal stents (BMS), the relative risk of stent thrombosis and adverse cardiovascular events is unclear. Although dual antiplatelet therapy (DAPT) beyond 1 year provides ischemic event protection after DES, ischemic event risk is perceived to be less after BMS, and the appropriate duration of DAPT after BMS is unknown. To compare (1) rates of stent thrombosis and major adverse cardiac and cerebrovascular events (MACCE; composite of death, myocardial infarction, or stroke) after 30 vs 12 months of thienopyridine in patients treated with BMS taking aspirin and (2) treatment duration effect within the combined cohorts of randomized patients treated with DES or BMS as prespecified secondary analyses. International, multicenter, randomized, double-blinded, placebo-controlled trial comparing extended (30-months) thienopyridine vs placebo in patients taking aspirin who completed 12 months of DAPT without bleeding or ischemic events after receiving stents. The study was initiated in August 2009 with the last follow-up visit in May 2014. Continued thienopyridine or placebo at months 12 through 30 after stent placement, in 11,648 randomized patients t...Continue Reading

Associated Clinical Trials

Citations

Feb 20, 2016·Journal of the American College of Cardiology·David R Holmes, Michael J Mack
Aug 1, 2015·Expert Review of Cardiovascular Therapy·Lee Chang, Robert W Yeh
Jan 29, 2016·JAAPA : Official Journal of the American Academy of Physician Assistants·Cortney M Mospan
Nov 21, 2015·European Heart Journal·Laura MauriUNKNOWN DAPT Study Investigators
Jan 13, 2016·Current Atherosclerosis Reports·Joseph Walker KeachThomas M Maddox
Jan 23, 2016·JACC. Cardiovascular Interventions·James B HermillerUNKNOWN DAPT Study Investigators
Jan 23, 2016·JACC. Cardiovascular Interventions·David R Holmes, Charanjit S Rihal
Mar 12, 2016·JACC. Cardiovascular Interventions·David E Kandzari
Oct 31, 2015·Journal of the American College of Cardiology·Robert W YehLaura Mauri
Mar 21, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Vigyan V Bang, Michael S Levy
Mar 20, 2015·Journal of the American College of Cardiology·Robert W YehUNKNOWN DAPT Study Investigators
Aug 14, 2015·Journal of the American College of Cardiology·Gilles MontalescotRoxana Mehran
May 4, 2016·Current Atherosclerosis Reports·Michael GilletteHani Jneid
May 4, 2016·The Canadian Journal of Cardiology·Mina Owlia, Sripal Bangalore
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Gianluigi SavaresePasquale Perrone-Filardi
Apr 6, 2016·Journal of the American College of Cardiology·Dean J KereiakesUNKNOWN DAPT Study Investigators
Jun 11, 2016·European Heart Journal·George Kassimis, Adrian P Banning
Jun 17, 2016·Expert Opinion on Pharmacotherapy·Yongwhi ParkDominick J Angiolillo
Jul 28, 2016·Journal of Endourology·Mary E WestermanAmy E Krambeck
Oct 24, 2015·JACC. Cardiovascular Interventions·Dean J KereiakesUNKNOWN DAPT Study Investigators
Sep 30, 2016·Expert Opinion on Pharmacotherapy·Piotr AdamskiJacek Kubica
Feb 10, 2017·Nature Reviews. Cardiology·Yosuke MiyazakiPatrick W Serruys
Mar 15, 2018·Journal of Cardiovascular Medicine·Simone Grotti, Leonardo Bolognese
Oct 19, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marco ValgimigliUNKNOWN ESC Scientific Document Group
Jun 21, 2017·Journal of Pharmacy Practice·Jacob D SumnerAndrew Smith
Nov 15, 2017·Therapeutic Advances in Cardiovascular Disease·Diego CastiniStefano Carugo
Nov 20, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Neil J WimmerScott Kinlay
Aug 31, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Miguel Sousa-UvaUNKNOWN ESC Scientific Document Group
Jan 23, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Franz-Josef NeumannMichael O Zembala
Aug 31, 2018·European Heart Journal·Franz-Josef NeumannUNKNOWN ESC Scientific Document Group

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