Antiplatelet Therapy for Secondary Prevention of Vascular Disease Complications

Current Atherosclerosis Reports
Rahul R GoliJay Giri

Abstract

Platelets are activated upon interaction with injured vascular endothelium to form a primary hemostatic plug. Pathogenic thrombosis driven by platelet aggregation can occur in the setting of vascular disease leading to ischemic events. The use of antiplatelet agents has become a mainstay for prevention of the secondary complications of vascular disease. This review summarizes seminal and recent literature related to this area. Aspirin is a cornerstone of antiplatelet therapy for coronary artery disease and cerebrovascular disease for prevention of myocardial infarction, stroke, and vascular death. Alternative antiplatelet agents have shown promise for use in patients with peripheral artery disease though further validation is necessary. Dual antiplatelet therapy (DAPT) with clopidogrel, prasugrel, or ticagrelor, and aspirin demonstrates benefit in patients with higher thrombotic risk. However, use of DAPT predictably increases bleeding risk, thus limiting mortality benefit. Individualization of DAPT to patient-specific features is an area of active research with the development the DAPT score and pharmacogenomic approaches. Application of pharmacogenetic data could allow for a precision medicine approach to tailoring antiplatel...Continue Reading

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Jul 9, 2020·Biomedical Optics Express·Darya V SpiryovaAlexander E Moskalensky
Jun 12, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Andrea SantucciClaudio Cavallini
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bang-Yue LuoJing-Wei Shao
Apr 26, 2018··Oleg Y. KarmatskihAlexei Y. Vorob'ev

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