Abstract
Activities of BAY 12-8039 against 205 pneumococci were tested by agar dilution. MICs (in micrograms per milliliter) at which 50 and 90% of the isolates are inhibited (MIC50s and MIC90s, respectively) were 0.125 and 0.25 (BAY 12-8039), 2.0 and 4.0 (ciprofloxacin and ofloxacin), and 0.25 and 0.5 (sparfloxacin). Beta-lactam MIC50s and MIC90s for penicillin-susceptible, -intermediate, and -resistant strains, in that order, were 0.016 and 0.03, 0.25 and 2.0, and 2.0 and 4.0 (amoxicillin); 0.03 and 0.06, 0.25 and 4.0, and 4.0 and 8.0 (ampicillin); 0.03 and 0.06, 0.5 and 4.0, and 4.0 and 8.0 (cefuroxime); and 0.03 and 0.125, 0.25 and 2.0, and 4.0 and 8.0 (cefpodoxime). At two times their MICs after 24 h, BAY 12-8039, ciprofloxacin, ampicillin, and cefuroxime were uniformly bactericidal (99.9% killing) against 12 strains; other compounds were bactericidal at four times their MICs.
References
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S K SpanglerP C Appelbaum
Oct 1, 1992·Antimicrobial Agents and Chemotherapy·L K McDougalF C Tenover
Jun 1, 1992·The Pediatric Infectious Disease Journal·I R Friedland, G R Istre
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R MunozA Tomasz
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R Jacobs
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Aug 1, 1988·Antimicrobial Agents and Chemotherapy·R WiseJ M Andrews
Jun 1, 1995·The Journal of Antimicrobial Chemotherapy·G A PankuchP C Appelbaum
Jan 1, 1995·The Journal of Antimicrobial Chemotherapy·G A PankuchP C Appelbaum
Aug 11, 1994·The New England Journal of Medicine·I R Friedland, G H McCracken
Mar 1, 1994·Antimicrobial Agents and Chemotherapy·E Wakabayashi, S Mitsuhashi
Feb 1, 1993·The Journal of Antimicrobial Chemotherapy·S K SpanglerP C Appelbaum
Sep 1, 1995·The Pediatric Infectious Disease Journal·S L BlockS A Chartrand
May 1, 1996·Antimicrobial Agents and Chemotherapy·G V DoernA M Rauch
Jul 1, 1996·Antimicrobial Agents and Chemotherapy·G A PankuchP C Appelbaum
Nov 1, 1996·Chemotherapy·A DalhoffR Endermann
Jan 1, 1997·Antimicrobial Agents and Chemotherapy·J M WoodcockR Wise
Citations
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Frederick A BrownePeter C Appelbaum
Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·A PongC C Sanders
Dec 10, 1999·The Journal of Antimicrobial Chemotherapy·R WilsonB Sommerauer
Mar 16, 2000·Drugs·J A Balfour, H M Lamb
Mar 24, 2000·Pharmacotherapy·C H Nightingale
May 26, 2006·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·D F SahmC Thornsberry
Oct 3, 1999·Antimicrobial Agents and Chemotherapy·M MüllerH G Eichler
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Dianne B HoellmanPeter C Appelbaum
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Lois M EdniePeter C Appelbaum
Nov 24, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shuyun XuWeining Xiong
Feb 15, 2001·Expert Opinion on Investigational Drugs·J M Blondeau
Mar 16, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A DalhoffG Tillotson
Mar 25, 2009·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Oct 17, 2007·Antimicrobial Agents and Chemotherapy·Catherine ClarkPeter C Appelbaum
Oct 10, 1998·Clinical Microbiology Reviews·S L Kaplan, E O Mason
Mar 13, 1999·Journal of Clinical Microbiology·P R HsuehK T Luh
Oct 23, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I FrédénucciJ Tous
Jan 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P C AppelbaumH F Khorakiwala