PMID: 9420061Jan 7, 1998Paper

Antipneumococcal activity of BAY 12-8039, a new quinolone, compared with activities of three other quinolones and four oral beta-lactams

Antimicrobial Agents and Chemotherapy
M A VisalliP C Appelbaum

Abstract

Activities of BAY 12-8039 against 205 pneumococci were tested by agar dilution. MICs (in micrograms per milliliter) at which 50 and 90% of the isolates are inhibited (MIC50s and MIC90s, respectively) were 0.125 and 0.25 (BAY 12-8039), 2.0 and 4.0 (ciprofloxacin and ofloxacin), and 0.25 and 0.5 (sparfloxacin). Beta-lactam MIC50s and MIC90s for penicillin-susceptible, -intermediate, and -resistant strains, in that order, were 0.016 and 0.03, 0.25 and 2.0, and 2.0 and 4.0 (amoxicillin); 0.03 and 0.06, 0.25 and 4.0, and 4.0 and 8.0 (ampicillin); 0.03 and 0.06, 0.5 and 4.0, and 4.0 and 8.0 (cefuroxime); and 0.03 and 0.125, 0.25 and 2.0, and 4.0 and 8.0 (cefpodoxime). At two times their MICs after 24 h, BAY 12-8039, ciprofloxacin, ampicillin, and cefuroxime were uniformly bactericidal (99.9% killing) against 12 strains; other compounds were bactericidal at four times their MICs.

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Citations

Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Frederick A BrownePeter C Appelbaum
Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·A PongC C Sanders
May 26, 2006·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·D F SahmC Thornsberry
Oct 3, 1999·Antimicrobial Agents and Chemotherapy·M MüllerH G Eichler
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Lois M EdniePeter C Appelbaum
Nov 24, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shuyun XuWeining Xiong
Feb 15, 2001·Expert Opinion on Investigational Drugs·J M Blondeau
Mar 16, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A DalhoffG Tillotson
Mar 25, 2009·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Oct 10, 1998·Clinical Microbiology Reviews·S L Kaplan, E O Mason
Oct 23, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I FrédénucciJ Tous
Jan 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P C AppelbaumH F Khorakiwala

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