Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

Antimicrobial Agents and Chemotherapy
Lois M EdniePeter C Appelbaum

Abstract

The MICs of LBM415, a new peptide diformylase inhibitor, were evaluated and ranged from 0.03 to 4.0 microg/ml for 300 pneumococci, irrespective of their beta-lactam, macrolide, and quinolone susceptibilities. By comparison, vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin were also active, with MICs </=2.0 microg/ml. Gatifloxacin and moxifloxacin were the most active quinolones tested, while the MICs of the beta-lactams rose with those of penicillin G. LBM415 at two times the MIC was bactericidal (99.9% killing) against six strains after 24 h.

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Citations

Jul 15, 2009·Antimicrobial Agents and Chemotherapy·Colin S OsborneNeil S Ryder
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Tatiana BogdanovichPeter C Appelbaum
Sep 30, 2009·Antimicrobial Agents and Chemotherapy·Ruth E CaughlanCharles R Dean
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Mar 13, 2013·Antimicrobial Agents and Chemotherapy·Karen O'DwyerDeborah Butler
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Thomas R FritscheRonald N Jones
Jun 18, 2009·Expert Opinion on Therapeutic Targets·Anshika SharmaSadhna Sharma
Mar 11, 2005·Expert Opinion on Investigational Drugs·Michael N Alekshun
Sep 8, 2005·Expert Opinion on Investigational Drugs·D Chen, Z Yuan
Jul 9, 2013·Expert Opinion on Drug Discovery·Michio KurosuKatsuhiko Mitachi
Oct 4, 2005·Clinical Therapeutics·Megan Nguyen, Eunice P Chung
Aug 16, 2005·Current Opinion in Microbiology·Peter C Appelbaum, Michael R Jacobs
Nov 18, 2005·Biochemical Pharmacology·Zhengyu Yuan, Richard J White
Dec 1, 2007·Journal of Biochemistry and Molecular Biology·Joon Kyu ParkEunice Eunkyeong Kim
Jul 1, 2011·Clinical Pharmacology and Therapeutics·P RolanT G Evans
Jan 15, 2005·The Journal of Antimicrobial Chemotherapy·Jan M BellRonald N Jones

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