Abstract
The search for antiviral agents against vesicular stomatitis virus, herpes simplex virus type 1 and poliovirus type 2 in plants extracts, led to the isolation of two antipoliovirus flavonoids from the medicinal plant Psiadia dentata (Cass.) DC, Asteraceae: 3-methylkaempferol and 3,4'-dimethylkaempferol. The antipoliovirus activity of both compounds was estimated by comparison with 3-methylquercetin, guanidine and Ro-090179. The most potent inhibitor of poliovirus replication was 3-methylkaempferol, and therefore we investigated its mechanism of action. We showed, using the inhibition of [3H]uridine incorporation in viral RNA and performing a dot-blot with one RNA probe specific for the poliovirus genomic strand RNA, that 3-methylkaempferol inhibits the genomic RNA synthesis of poliovirus.
References
Nov 1, 1992·Virology·A IrurzunL Carrasco
Feb 1, 1991·Journal of Medicinal Chemistry·N De MeyerA J Vlietinck
Sep 1, 1991·Schizophrenia Research·K T MueserR L Morrison
Oct 1, 1987·Journal of Virology·J L Castrillo, L Carrasco
Jul 15, 1986·Virology·J L CastrilloL Carrasco
Nov 1, 1986·Journal of Virology·S E Pincus, E Wimmer
May 22, 1986·Journal of Immunological Methods·F Denizot, R Lang
Oct 1, 1986·Antiviral Research·W H PrusoffM Zucker
Sep 1, 1985·Chemical & Pharmaceutical Bulletin·Y TsuchiyaN Morita
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·H IshitsukaY Suhara
Jan 1, 1994·Pharmacology & Therapeutics·L Carrasco
Jun 1, 1997·Journal of Virology·I V Sandoval, L Carrasco
Apr 3, 1998·Planta medica·A J VlietinckL A Pieters
Jun 19, 1998·Journal of Medicinal Chemistry·J A BeutlerM R Boyd
Aug 19, 2000·Antiviral Chemistry & Chemotherapy·H A Rotbart
Apr 12, 2001·Biochemistry·A Irurzun, L Carrasco
Dec 1, 1984·Planta medica·L Van HoofA J Vlietinck
Citations
Sep 10, 2014·Virus Research·Kun QianAi-jian Qin
May 15, 2012·Archives of Virology·Kyoko HayashiToshimitsu Hayashi
May 17, 2011·Pharmacology & Therapeutics·Beatrice MercorelliArianna Loregian
Jul 6, 2010·Journal of Ethnopharmacology·M C JonvilleJ Legault
Jan 20, 2009·Phytotherapy Research : PTR·Thelma OnozatoTânia Ueda-Nakamura
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Mar 26, 2010·Virology·Nancy Y VillaGrant McFadden
Aug 29, 2006·Antiviral Research·Sabrina TaitLucia Fiore
Apr 25, 2006·Biochemical and Biophysical Research Communications·So-Young KimHee-Sun Kim
Sep 29, 2005·Antiviral Research·David L EversEng-Shang Huang
Jul 15, 2009·The Journal of Nutritional Biochemistry·Aline AndresMark S Kuhlenschmidt
Nov 29, 2014·Pharmaceutical Biology·Ogbole Omonike OluyemisiMuhammad Iqbal Choudhary
Jan 26, 2012·PloS One·Ting ZhangQi Jin
Feb 12, 2020·Viruses·Salima Lalani, Chit Laa Poh
Sep 8, 2010·Pharmaceutical Biology·Lucia Regina Rocha MartinsDiógenes Aparício Garcia Cortez