PMID: 11900347Mar 20, 2002Paper

Antipoliovirus flavonoids from Psiadia dentata

Antiviral Chemistry & Chemotherapy
V RobinL Carrasco

Abstract

The search for antiviral agents against vesicular stomatitis virus, herpes simplex virus type 1 and poliovirus type 2 in plants extracts, led to the isolation of two antipoliovirus flavonoids from the medicinal plant Psiadia dentata (Cass.) DC, Asteraceae: 3-methylkaempferol and 3,4'-dimethylkaempferol. The antipoliovirus activity of both compounds was estimated by comparison with 3-methylquercetin, guanidine and Ro-090179. The most potent inhibitor of poliovirus replication was 3-methylkaempferol, and therefore we investigated its mechanism of action. We showed, using the inhibition of [3H]uridine incorporation in viral RNA and performing a dot-blot with one RNA probe specific for the poliovirus genomic strand RNA, that 3-methylkaempferol inhibits the genomic RNA synthesis of poliovirus.

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Citations

May 17, 2011·Pharmacology & Therapeutics·Beatrice MercorelliArianna Loregian
Jan 20, 2009·Phytotherapy Research : PTR·Thelma OnozatoTânia Ueda-Nakamura
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Aug 29, 2006·Antiviral Research·Sabrina TaitLucia Fiore
Apr 25, 2006·Biochemical and Biophysical Research Communications·So-Young KimHee-Sun Kim
Jul 15, 2009·The Journal of Nutritional Biochemistry·Aline AndresMark S Kuhlenschmidt
Nov 29, 2014·Pharmaceutical Biology·Ogbole Omonike OluyemisiMuhammad Iqbal Choudhary
Feb 12, 2020·Viruses·Salima Lalani, Chit Laa Poh
Sep 8, 2010·Pharmaceutical Biology·Lucia Regina Rocha MartinsDiógenes Aparício Garcia Cortez

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