Antiprogestins mediate differential effects on glucocorticoid receptor remodeling of chromatin structure.

The Journal of Biological Chemistry
C J FryerTrevor K Archer

Abstract

We examined the mechanism(s) by which the progesterone receptor (PR) is able to inhibit glucocorticoid receptor (GR) activation from the mouse mammary tumor virus (MMTV) promoter in vivo. Using specific hormone antagonists, we demonstrate that the PR complexed with an type II antiprogestin blocks glucocorticoid-induced activation of the MMTV promoter. However, when complexed with a type I antiprogestin the PR is unable to block glucocorticoid-induced activation. PR repression of GR activity results from the inhibition of the ability of the GR to remodel chromatin such that the antiprogestin-occupied/PR prevents the glucocorticoid induced assembly of a preinitiation complex at MMTV promoter. These experiments suggest that the specific chromatin organization of the MMTV promoter provides a mechanism for regulating cross-talk between the GR and PR in vivo.

References

Dec 11, 1990·Molecular Endocrinology·S K NordeenC A Hutchison
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K E NoonanI B Roninson
Jul 1, 1989·Molecular and Cellular Biology·J CharronJ Drouin
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Jun 1, 1994·Current Biology : CB·A P Wolffe
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·G L HagerC L Smith
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C A BeckD P Edwards
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M T BocquelH Gronemeyer
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Apr 15, 1996·Genes & Development·R E KingstonA N Imbalzano
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·W LiuD Pearce

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Citations

Oct 4, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Bonnie J Deroo, Trevor K Archer
Dec 26, 2006·The Journal of Biological Chemistry·Pratibha B Hebbar, Trevor K Archer
May 25, 2002·Molecular and Cellular Biology·Bonnie J DerooTrevor K Archer
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zheng LiuBert W O'Malley
Mar 20, 2012·Biochimica Et Biophysica Acta·Heather A KingTrevor K Archer
Apr 9, 2008·Journal of Cellular Biochemistry·Irene M WolfDonald B DeFranco
Dec 7, 2007·Journal of Cellular and Molecular Medicine·Paraskevi Moutsatsou, Athanasios G Papavassiliou
Apr 20, 2011·The FEBS Journal·Malgorzata WienchGordon L Hager
Apr 18, 2002·The Journal of Biological Chemistry·Bonnie J Deroo, Trevor K Archer
Feb 10, 1999·The American Journal of Physiology·V P FominR A Word
Jun 23, 2001·Oncogene·B J Deroo, T K Archer

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