Antiproliferative activity of Pteleopsis suberosa leaf extract and its flavonoid components in human prostate carcinoma cells

Planta medica
Marinella De LeoAlessandra Russo

Abstract

In this work we describe the chemical composition of Pteleopsis suberosa (Combretaceae) leaf extract and its biological activity against androgen-insensitive human prostate cancer cells (DU-145). The methanol extract of the plant leaves exhibited activity against tumor cell growth. Fractionation of this active extract led to the isolation and identification of sixteen flavonoids, including gallocatechin and flavonols having kaempferol, quercetin, and myricetin as aglycones. Among the myricetin derivatives, myricetin 3-O-(3''-acetyl)-alpha-L-arabinopyranoside (1) and myricetin 3-O-(4''-acetyl)-alpha- L-arabinopyranoside (2) are now reported for the first time. Six compounds, myricetin 3-O-alpha- L-rhamnopyranoside (4), myricetin 3-O-beta-D-galactopyranoside (7), myricetin 3-O-(6''-galloyl)-beta-D-galactopyranoside (9), myricetin 3-O-beta-D-xylopyranoside (10), myricetin 3-O-alpha-L-arabinofuranoside (12), and gallocatechin (14), exhibited significant activity, reducing cell vitality and inducing apoptosis via the caspase-dependent pathway in DU-145 cells that can be, in part, correlated to modulation of redox-sensitive mechanisms.

Citations

May 24, 2008·Natural Product Reports·Nigel C Veitch, Renée J Grayer
Nov 29, 2013·International Journal of Molecular Sciences·Feng XieLiqun Zhou
Feb 20, 2014·International Journal of Molecular Sciences·Hyun Sook LeeJung Han Yoon Park
Dec 7, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Pei-Shan CaiJin-Lan Ruan
Dec 6, 2008·Journal of Ethnopharmacology·Mikael E PedersenAnna K Jäger
Nov 16, 2010·Biochemical and Biophysical Research Communications·Diane KrillPeter D Moeller
Nov 20, 2012·The Journal of Nutritional Biochemistry·Alexander BergerMichael Bitzer
Feb 20, 2016·Nutrients·Deepak Kumar SemwalAlvaro Viljoen
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jorge F S FerreiraArne Heyerick
Aug 3, 2020·BMC Complementary Medicine and Therapies·Yasaman TaheriJavad Sharifi-Rad

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