Antiproliferative activity of spinasterol isolated of Stegnosperma halimifolium (Benth, 1844)

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Salvador Enrique Meneses-SagreroRamón Enrique Robles-Zepeda

Abstract

Cancer is the major cause of death in the world, representing a significant public health problem. Plants have been shown as a great source of secondary metabolites with anticancer activity. The aim of this work was evaluated the antiproliferative activity of the methanolic extracts, chemical fractions and the compound spinasterol isolated of medicinal plant Stegnosperma halimifolium. The methanolic extracts of stem, leaf and stem/leaf was obtained by maceration. The methanolic extract of stem was purified by successive extractions with solvents as n-hexane, ethyl acetate and ethanol. The n-hexane fraction was separated by column chromatographic and monitored by thin layer chromatographic. The compound spinasterol was characterized by 1H NMR, 13C NMR and Mass Spectrometry. Methanolic extracts, chemical, chromatographic fractions and spinasterol was evaluated against RAW 264.7, M12.C3.F6, PC-3, LS-180, A549 and HeLa cancer cell lines by the standardized method MTT for determinate the antiproliferative activity. Methanolic extract of stem shown the better antiproliferative activity against the murine macrophage cancer cell line RAW 264.7. n-Hexane chemical fraction shown antiproliferative activity against human alveolar cancer ce...Continue Reading

Citations

Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Rodrigo SalazarDiego Soto-Cabrera
May 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maqsood AhmedJamil Shafi
Mar 12, 2020·International Journal of Molecular Sciences·Cátia S D OliveiraArmando J D Silvestre
Jun 15, 2021·Journal of Toxicology and Environmental Health. Part a·José Rafael da Silva AraújoPedro Marcos de Almeida

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Methods Mentioned

BETA
column chromatography
ELISA
Nuclear Magnetic Resonance
NMR

Software Mentioned

GraphPad Prism
SPSS
GraphPad

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