Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yasantha AthukoralaYou-Jin Jeon

Abstract

The potential antiproliferative and antiradical activities of an enzymatic extract of Ecklonia cava together with its crude polysaccharide (CpoF) and crude polyphenolic fractions (CphF) were evaluated in vitro. Tested extracts showed strong selective cell proliferation inhibition on all cancer cell lines tested, especially CphF extract, containing high polyphenol amount, showed 5.1 microg/ml of IC(50) value on murine colon cancer (CT-26) cell line. According to the nuclear staining experiment, antiproliferative effect of CphF was associated with apoptotic cell demise in CT-26. In addition, The CphF at 5 microg/ml scavenged 70% of DPPH radical, which is much higher than those of BHA and BHT at same concentration. Further more CphF exhibited interesting antiradical properties, expressed by its capacity to scavenge superoxide anion (O(2)(-)), hydrogen peroxide (H(2)O(2)) and hydroxyl radical (OH()). In reducing power assay, CphF extract at 5 microg/ml was found to be as high as that of BHT at same concentration. Also, in total antioxidant assay the effect of CphF at 50 microg/ml was equivalent or slightly higher than those of commercial counterparts at 5 microg/ml concentration. Taken together, the CphF may be a promising alternat...Continue Reading

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Citations

May 24, 2007·Marine Biotechnology·Rohan KarawitaYou-Jin Jeon
Feb 1, 2011·Journal of Food Science and Technology·Qian SunYongkang Luo
Sep 7, 2011·Journal of Agricultural and Food Chemistry·Zhen WuGuohua Zhao
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Jan 8, 2013·Bioscience, Biotechnology, and Biochemistry·Yang-Hee HongHyung Joo Suh
May 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hye Kyung Kim
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Apr 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Suk KongSe-Kwon Kim
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