Antiproliferative and cytotoxic effects of green coffee and yerba mate extracts, their main hydroxycinnamic acids, methylxanthine and metabolites in different human cell lines

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M Amigo-BenaventLaura Bravo

Abstract

This work aimed at studying the effects of green coffee bean (GCBE) and yerba mate (YME) extracts, their main phenolic components (5-caffeoylquinic acid, 5-CQA; 3,5-dicaffeoylquinic acid, 3,5-DCQA) and metabolites (ferulic acid, FA; caffeic acid, CA; dihydrocaffeic acid, DHCA; and dihydroferulic acid, DHFA) along with caffeine (CAF) on the viability and proliferation of different human cell lines. Extracts (10-1000 μg/mL) and standards (10-1000 μM) were assayed in colon (Caco-2), lung (A549), oesophageal (OE-33), urinary bladder (T24) human carcinoma cells, and a non-cancer cell line (CCD-18Co). YME significantly reduced viability of cancer cells at all assayed concentrations, the higher doses also reducing cell proliferation. GCBE effects on cell viability were more effective at 100 and 1000 μg/mL, showing modest effects on cell proliferation. The highest doses of 5-CQA and 3,5-DCQA reduced cell viability and proliferation in all cell lines, whereas FA, DHCA and DHFA had lower and variable effects. Caffeine had no effect. Dietary-attainable concentrations (0.1, 1 and 10 μg/mL) of YME were tested for cytotoxicity and reactive oxygen species generation, showing no cytotoxic effect. Low concentrations of all tested compounds were...Continue Reading

Citations

Apr 7, 2018·Critical Reviews in Food Science and Nutrition·Nevin SanlierIlker Atik
Jul 3, 2019·Prostate Cancer·Olivia LodiseS Balakrishna Pai
May 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marlon OsorioCristina Castro
May 8, 2020·Oxidative Medicine and Cellular Longevity·Paola AielloWesam Kooti
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Michael N CliffordGary Williamson
Jun 12, 2021·Oxidative Medicine and Cellular Longevity·Ayelén D NigraGermán A Gil
Nov 10, 2020·Toxicon : Official Journal of the International Society on Toxinology·Cristina JuanAna Juan-García

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