Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell

Cancer Investigation
V FortinoE Maioli

Abstract

Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-treated MCF-7 breast cancer cell and found that: PMA induced growth arrest and inhibited cell death; PMA activated ERKs, which, in turn, induced p21; and inhibitors of ERK (PD98059) and PKC (GF109203X) prevented p21 induction and abolished the PMA survival effect. We conclude that PMA inhibits MCF-7 cell growth and simultaneously stimulates cell survival; both responses are linked to ERK-dependent and p53-independent p21 induction.

References

Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Mar 20, 2002·Molecular Pharmacology·Marcelo G Kazanietz
Feb 6, 2003·Cellular and Molecular Life Sciences : CMLS·V FortinoE Maioli
Mar 5, 2004·Breast Cancer Research and Treatment·Catherine F Welsh
Mar 18, 2004·British Journal of Cancer·E Maioli, V Fortino
Jan 15, 2005·Biochemical and Biophysical Research Communications·Goro YokoyamaKazuo Shirouzu
May 3, 2005·The Journal of Biological Chemistry·Chengfeng YangMarcelo G Kazanietz
May 17, 2005·The Journal of Biological Chemistry·Kenji SakakibaraBo Liu
Feb 4, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Claudia TorricelliEmanuela Maioli
Feb 28, 2006·Cellular and Molecular Life Sciences : CMLS·E MaioliV Fortino
Jun 8, 2006·Methods in Enzymology·Que T Lambert, Gary W Reuther
Aug 25, 2006·Molecular Cancer Therapeutics·Steven E CanfieldDavid J McConkey

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Citations

Aug 28, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jeong-Mi KimYoung-Rae Lee
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Elena DaveriEmanuela Maioli
Oct 20, 2011·Analytical Chemistry·Toshitaka OkaYosuke Katsumura
Nov 16, 2010·In Vitro Cellular & Developmental Biology. Animal·Claudia TorricelliEmanuela Maioli
May 24, 2018·Current Medicinal Chemistry·Ka Ming WongYung H Wong

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