Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines

European Journal of Medicinal Chemistry
Luciana K KohnWanda P Almeida

Abstract

In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.

References

Jun 5, 1991·Journal of the National Cancer Institute·A MonksA Vaigro-Wolff
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M WilliamsonA Meister
May 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T J McCarthyG Witz
May 30, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A VerdecchiaF Berrino
Jul 2, 2005·Bioorganic & Medicinal Chemistry Letters·Osvaldo J DonadelJosé M Padrón

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Citations

Aug 9, 2017·Mediators of Inflammation·Glaucia V Faheina-MartinsDemetrius A M Araújo
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amauri Francisco da SilvaOtávio Luís de Santana
Aug 26, 2010·Chemical Reviews·Deevi BasavaiahSatpal Singh Badsara
Jan 5, 2011·European Journal of Medicinal Chemistry·Suresh KumarRajiv Kumar
May 29, 2012·Bioorganic & Medicinal Chemistry·Claudio G Lima-Junior, Mário L A A Vasconcellos

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