Antiproliferative effect of catechin in GRX cells

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Cristina Machado Bragança de MoraesJarbas Rodrigues de Oliveira

Abstract

The phenolic compounds present in cocoa seeds have been studied regarding health benefits, such as antioxidant and anti-inflammatory activities. Fibrosis is a wound healing response that occurs in almost all patients with chronic liver injury. A large number of cytokines and soluble intercellular mediators are related to changes in the behavior and phenotype of the hepatic stellate cell (HSC) that develop a fibrogenic and contractile phenotype leading to the development of fibrosis. The objective of this study was to assess the catechin effect in GRX liver cells in activities such as cell growth and inflammation. The GRX cells treatment with catechin induced a significant decrease in cell growth. This mechanism does not occur by apoptosis or even by autophagy because there were no alterations in expression of caspase 3 and PARP (apoptosis), and LC3 (autophagy). The expression of p27 and p53 proteins, regulators of the cell cycle, showed increased expression, while COX-2 and IL-6 mRNA showed a significant decrease in expression. This study shows that catechin decreases cell growth in GRX cells and, probably, this decrease does not occur by apoptosis or autophagy but through an anti-inflammatory effect and cell cycle arrest. Cate...Continue Reading

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Citations

Aug 21, 2013·Cell Biochemistry and Biophysics·Shanna BitencourtJarbas Oliveira
Oct 23, 2013·European Journal of Pharmacology·Fernanda C de MesquitaJarbas R de Oliveira
Aug 22, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shanna BitencourtJarbas R de Oliveira
Dec 20, 2013·Cell Biology International·Cristina Machado Bragança de MoraesJarbas Rodrigues de Oliveira
Jul 15, 2015·BMC Complementary and Alternative Medicine·Kyungjin LeeHo-Young Choi
Jan 1, 2015·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kristýna Schneiderová, Karel Šmejkal

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