PMID: 2124936Sep 1, 1990Paper

Antiproliferative effects of natural interferon beta alone and in combination with natural interferon gamma on human breast carcinomas in nude mice

Breast Cancer Research and Treatment
L OzzelloC M DeRosa

Abstract

Nude mice bearing bilateral xenografts of human breast carcinoma cells (MCF-7 and BT20) were treated with 2 or 45-day cycles of intralesional (i.l.) injections of human natural interferon beta (nIFN-beta) alone or in combination with human natural interferon gamma (nIFN-gamma). The injections were administered to only 1 of the 2 tumors in each animal, thus making it possible to assess at the same time local therapeutic effects in the injected tumors and systemic effects in the contralateral ones. When n-IFN-beta was used as a single agent only mild local antitumor effects and virtually no systemic effects were observed. In contrast, the combined administration of nIFN-beta/nIFN-gamma produced marked antiproliferative effects, presumably as a result of the synergistic action of type I and type II IFNs. These effects ranged from complete regression documented histologically in 2 MCF-7 tumors to varying degrees of growth inhibition with persistence of residual microscopic or grossly detectable tumor. Local effects were more pronounced than systemic effects. The therapeutic efficacy of nIFN-beta proved to be greater than that of recombinant interferon beta (rIFN-beta). In MCF-7 tumors nIFN-beta appeared to be less effective than nI...Continue Reading

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Citations

Jan 1, 1996·Biotherapy·F Burke, F R Balkwill
Dec 1, 1991·Pharmacology & Therapeutics·H Thomas, F R Balkwill
Oct 9, 2003·The Journal of Biological Chemistry·Yasunori HoshiyaShyamala Maheswaran
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Weixin LuIsaiah J Fidler
Oct 20, 2005·The Cochrane Database of Systematic Reviews·W SomboonpornR Bell
Jan 24, 2012·Oncology Reports·Yi RenDali Tian
Jan 22, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·
Jan 1, 2014·Archives of Pathology & Laboratory Medicine·Xiaofang YangAshraf Khan

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