Antiproliferative Effects of New Dimeric Ellagitannin from Cornus alba in Prostate Cancer Cells Including Apoptosis-Related S-Phase Arrest

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Kwan Hee ParkMin Won Lee

Abstract

Activity-guided isolation of 80% acetone extract of Cornus alba, which is traditionally used as an anti-inflammatory, hemostatic and diuretic in Korea, yielded one novel compound, tentatively designated cornusiin H (13), together with 12 known compounds. The known compounds included four flavonoids (catechin (1), quercetin-3-O-β-D-glucuronide (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4)) and eight hydrolysable tannins (gallic acid (5), 2,6-di-O-galloyl-hamamelofuranoside (6), 2-galloyl-4-caffeoyl-L-threonic acid (7) 2,3-di-O-galloyl-4-caffeoyl-L-threonic acid (8), 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranoside (9), cornusiin B (10), cornusiin A (11) and camptothin B (12)). All compounds exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH)-free radical scavenging activity. Especially, the radical scavenging activities of 6 and 9-13 were higher than that of vitamin C. Compounds 9, 11, 12 and 13 inhibited the production of nitric oxide (NO) in lipopolysaccharide-stimulated RAW264.7 cells to the same degree as N(G)-Monomethyl-L-arginine (L-NMMA). When the antiproliferative effects of the isolated compounds were assessed in prostate cancer cells, the dimeric ellagitannins (11-13) selectively inh...Continue Reading

References

Jan 1, 1973·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·T Endo, H Taguchi
Dec 30, 1998·Archives of Pharmacal Research·D K Kim, J H Kwak
Mar 7, 2000·Phytochemistry·D LeeA D Kinghorn
May 21, 2003·Current Urology Reports·Ian YipDavid Chim
Feb 12, 2005·BJU International·Naomi M GadesSteven J Jacobsen
Mar 15, 2005·Experimental Gerontology·Gerold UntergasserPeter Berger
Jan 9, 2007·Phytochemistry·Orjan BjorøyOyvind M Andersen
May 11, 2007·Archives of Pharmacal Research·Dae-Young LeeNam-In Baek
Feb 3, 2009·Cancer Letters·Lakshmipathi KhandrikaHari K Koul
Jan 1, 2009·Molecular and Cellular Pharmacology·Elizabeth R RayburnRuiwen Zhang
Dec 25, 2010·Journal of Natural Products·Ki Hyun KimKang Ro Lee
Aug 29, 2014·Phytotherapy Research : PTR·Ester PaganoRaffaele Capasso

❮ Previous
Next ❯

Citations

Mar 17, 2017·Journal of Agricultural and Food Chemistry·Adriana NowakKrzysztof Kołodziejczyk
Oct 11, 2019·Nutrients·Seungjin NohBonglee Kim
Jan 17, 2019·Journal of Food and Drug Analysis·Anita ŚwierczewskaMonika E Czerwińska
Mar 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shailendra Kapoor
Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominika PrzybylskaIzabela Fecka
Jun 29, 2021·Mitochondrial DNA. Part B, Resources·Wangjun YuanYanxia He
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Hui ParkMin-Won Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
nuclear
circular dichroism
column chromatography
ELISA

Software Mentioned

Cell Quest

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.