Antiprotease therapy in cancer: hot or not?

Expert Opinion on Biological Therapy
Tamara T LahCornelis J F Van Noorden

Abstract

The activity of a set of peptidases (proteases) involved in cancer progression is collectively known as the cancer 'degradome'. Invasion and metastasis were initially considered as late events in cancer development and the processes in which proteases were involved. However, recent studies indicate that invasion and metastasis are not late events, but can occur during early stages as well. Moreover, other processes occurring in various stages of cancer progression are also protease-dependent, such as (upregulation of) cell proliferation, (downregulation of) apoptosis, involvement of white blood cells, angiogenesis and induction of multi-drug resistance. Proteolytic activity in tumours is regulated in a complex manner, as both genetically unstable cancer cells and stable stromal cells, such as fibroblasts, endothelial cells and inflammatory cells, are involved. In vitro studies and studies using animal models have clearly shown protease dependency of many processes in carcinogenesis. However, clinical trials using protease inhibitors have thus far been unsuccessful except for a few applications of matrix metalloprotease (MMP) inhibitors when used in combination with cytostatic anticancer agents and/or in the early stages of canc...Continue Reading

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Jan 6, 2012·Applied Microbiology and Biotechnology·Jerica Sabotič, Janko Kos
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Feb 29, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Charlotte H J R JansenCornelis J F Van Noorden

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