PMID: 15341692Sep 3, 2004Paper

Antiproteinuric effect of RAS blockade: new mechanisms

Current Hypertension Reports
Markus LassilaKarin Jandeleit-Dahm

Abstract

Experimental and clinical studies have shown that blockade of the renin-angiotensin system (RAS) is effective in reducing proteinuria in conditions such as diabetes by reducing systemic and intraglomerular hydrostatic pressure. However, increasing evidence suggests that nonhemodynamic effects, such as preservation of the podocyte slit diaphragm structure and function, may also mediate the antiproteinuric effects of RAS blockade. In this review, we analyze in detail the evidence for known and novel mechanisms considered to play important roles in mediating the antiproteinuric effect of RAS blockers, with a particular focus on diabetic nephropathy.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraM Steffes
Sep 12, 1998·Kidney International·E A JaimesL Raij
Nov 11, 1999·Oncogene·F Mercurio, A M Manning
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K SharmaE J Lewis
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D KoyaR Kikkawa
Jun 1, 2000·Kidney International. Supplement·P HovindH H Parving
Sep 21, 2000·Kidney International. Supplement·D R ChaN H Won
Oct 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G T ShinD Kim
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·An S DE VrieseNorbert H Lameire
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G JerumsC Tsalamandris
Jun 21, 2001·Molecular and Cellular Biology·D B DonovielD R Powell
Sep 13, 2001·Clinical and Experimental Pharmacology & Physiology·K SugimotoA Fujimura
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·P AaltonenH Holthöfer
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·O V SakharovaB M Brenner
Nov 17, 2001·Hypertension·E M de CavanaghL Ferder
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Mona F MelhemFrederick R DeRubertis
Jan 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sachi HoshiMichio Nagata
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leileata M RussoWayne D Comper
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Maija RantanenHarry Holthöfer
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Zemin CaoMark E Cooper
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Darren J KellyRichard E Gilbert

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Citations

Aug 28, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomáš Seeman
May 19, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Q PanY-X Cheng
Mar 11, 2006·American Journal of Physiology. Renal Physiology·Mario B MarreroDouglas C Eaton
May 23, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joanne E Murphy-Ullrich

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