Antiprothombin antibodies and the diagnosis of antiphospholipid syndrome

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Olga AmengualTakao Koike

Abstract

The preliminary classification criteria for definite antiphospholipid syndrome (APS) include the presence of anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LA) as laboratory criteria. However, antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies comprising also antibodies against phospholipid-binding proteins or their complexes with phospholipids. Prothrombin is one of the antigen recognized by aPL. In the last decade, there has been increasing interest in antibodies against prothrombin alone and those against phosphatidylserine-prothrombin complex. The latter, phosphatidylserine-dependent antiprothrombin antibodies (aPT), have been closely associated with APS and LA. In this paper, we review the properties of antiprothrombin antibodies.

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Citations

Jul 7, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Trisha A RettigSherry D Fleming
Aug 30, 2005·Annals of the New York Academy of Sciences·Guido Valesini, Cristiano Alessandri
Jul 21, 2006·Annals of the New York Academy of Sciences·Nicoletta di SimoneAlessandro Caruso
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