Antiprotozoal activity of Melampyrum arvense and its metabolites

Phytotherapy Research : PTR
Hasan KirmizibekmezDeniz Tasdemir

Abstract

An activity guided isolation of the H(2)O subextract of the crude extract of Melampyrum arvense L. afforded iridoid glucosides: aucubin (1), melampyroside (2), mussaenoside (3), mussaenosidic acid (4), 8-epi-loganin (5); flavonoids: apigenin (6), luteolin (7), luteolin 7-O-β-glucopyranoside (8); a lignan glycoside dehydrodiconiferyl alcohol 9-O-β-glucopyranoside (9); and benzoic acid (10). β-Sitosterol (11) and a fatty acid mixture (12) were identified as the active principles of the CHCl(3) subextract. The structures of the isolates were elucidated by spectroscopic methods, while the composition of 12 was identified by GC-MS after methylation. Luteolin (7) appeared as the most active compound against Trypanosoma brucei rhodesiense and Leishmania donovani (IC(50) values 3.8 and 3.0 μg/mL). Luteolin 7-O-β-glucopyranoside (8) displayed the best antiplasmodial activity against Plasmodium falciparum (IC(50) value 2.9 μg/mL). This is the first detailed phytochemical study on Turkish M. arvense and the first report of the antiprotozoal effect of Melampyrum species and its constituents.

References

Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L G RochaJ M Barbosa-Filho
Dec 21, 2006·International Journal of Health Services : Planning, Administration, Evaluation·Debabar Banerji
Feb 1, 1985·Planta medica·H ArensB Ulbrich
Nov 19, 2008·Fitoterapia·Bhuwan B MishraVinod K Tiwari
Jan 14, 2009·Phytotherapy Research : PTR·D StajnerA Kapor
Nov 1, 1980·Journal of Natural Products·L J El-Naggar, J L Beal

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Citations

Dec 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramiro Quintanilla-LiceaMagda Elizabeth Hernández-García
Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli
Oct 25, 2014·Natural Product Research·Alessandro VendittiArmandodoriano Bianco
Mar 25, 2015·BioMed Research International·Laura MarínFelipe Lombó
Jun 20, 2019·Current Drug Targets·Pone Kamdem Boniface, Ferreira Igne Elizabeth
Mar 23, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Guilherme Arraché GonçalvesGilsane Lino von Poser
Aug 11, 2018·Journal of Natural Products·Yago S S Emiliano, Elmo E Almeida-Amaral

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