Antiprotozoal sesquiterpene pyridine alkaloids from Maytenus ilicifolia

Journal of Natural Products
Vânia A F F M SantosM Furlan

Abstract

As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC(50) values of 1.4 and 41.9 μM, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC(50) of 1.8 mM).

References

Aug 1, 1991·Journal of Ethnopharmacology·M L Souza-FormigoniE A Carlini
Mar 17, 1999·Journal of Natural Products·G M LarsonA T Sneden
Sep 8, 2000·Bioorganic & Medicinal Chemistry·A G GonzálezA G Ravelo
Jan 2, 2001·Parasitology Research·S Muelas-SerranoA Gómez-Barrio
May 26, 2001·Journal of Natural Products·H DuanD Li
Apr 3, 2002·Contraception·Tatiana Montanari, Estela Bevilacqua
Sep 19, 2003·Phytotherapy Research : PTR·Joaquim CorsinoMaysa Furlan
Oct 29, 2003·Trends in Parasitology·Julio A Urbina, Roberto Docampo
Nov 5, 2003·The Alkaloids. Chemistry and Biology·Luciano M Lião
Jan 24, 2004·Journal of Natural Products·Marvin J NúñezIsabel L Bazzocchi
Mar 27, 2004·Journal of Natural Products·Ayumi OhsakiJunko Takashima
Jul 29, 2006·Journal of Natural Products·Thales R CiprianiMarcello Iacomini
Dec 28, 2006·Journal of Natural Products·Emily L WhitsonChris M Ireland
Sep 28, 2007·Natural Product Reports·Jin-Ming GaoYasuo Konishi
Feb 26, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Patricia Marçal da CostaCláudia Pessoa
Oct 13, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vânia Aparecida de Freitas Formenton Macedo Dos SantosMaysa Furlan

❮ Previous
Next ❯

Citations

May 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Freddy A Bernal, Ericsson Coy-Barrera
Sep 27, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cássio Santana MeiraMilena Botelho Pereira Soares
Apr 16, 2016·Experimental Parasitology·Cássio Santana MeiraMilena Botelho Pereira Soares
Feb 5, 2015·Future Medicinal Chemistry·Stella PeñaGloria Serra
Sep 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dongsheng FanLi-Ping Bai
Jun 11, 2014·Antimicrobial Agents and Chemotherapy·Luiz Antônio DutraJean Leandro dos Santos
Dec 6, 2018·Organic & Biomolecular Chemistry·Takeru Miyakoshi, Hiroyuki Konno
Jul 26, 2013·Natural Product Reports·Braulio M Fraga
Nov 2, 2016·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Tailyn ZermianiRivaldo Niero
Aug 15, 2018·Journal of Natural Medicines·Dongsheng FanLi-Ping Bai
Mar 28, 2020·PloS One·Natalia C S CostaEduardo M Cilli
Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel Petinatti PavariniMaysa Furlan
Sep 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Letícia de AlmeidaMárcia A S Graminha
Mar 27, 2021·Natural Product Research·Hong Liang YeHai Xue Kuang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Yuan HuangJing-Quan Yuan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.