Antipsychotic agents for the treatment of substance use disorders in patients with and without comorbid psychosis

Journal of Clinical Psychopharmacology
Simon ZhornitskyStéphane Potvin

Abstract

Substance dependence has serious negative consequences upon society such as increased health care costs, loss of productivity, and rising crime rates. Although there is some preliminary evidence that atypical antipsychotic agents may be effective in treating substance dependence, results have been mixed, with some studies demonstrating positive and others negative or no effect. The present study was aimed at determining whether this disparity originates from that reviewers separately discussed trials in patients with (DD) and without (SD) comorbid psychosis. Using electronic databases, we screened the relevant literature, leaving only studies that used a randomized, double-blind, placebo-controlled or case-control design that had a duration of 4 weeks or longer. A total of 43 studies were identified; of these, 23 fell into the category of DD and 20 into the category of SD. Studies in the DD category suggest that atypical antipsychotic agents, especially clozapine, may decrease substance use in individuals with alcohol and drug (mostly cannabis) use disorders. Studies in the SD category suggest that atypical antipsychotic agents may be beneficial for the treatment of alcohol dependence, at least in some subpopulations of alcohol...Continue Reading

References

Dec 1, 1990·Postgraduate Medical Journal·M A Gillman, F J Lichtigfeld
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·A Ettenberg
Jan 16, 1989·Brain Research·P P Rompré, R A Wise
Jan 1, 1985·Psychopharmacology. Supplementum·J HyttelJ Arnt
Feb 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·G K ShawG Dunn
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·R J Barrett, D K White
Apr 15, 1995·Biological Psychiatry·J McEvoyJ Rose
Oct 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·G K ShawG Dunn
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·D Huston-LyonsC Kornetsky
May 16, 1996·The New England Journal of Medicine·J D HeissE H Oldfield
May 16, 1996·The New England Journal of Medicine·F H GawinP Jatlow
Apr 1, 1996·Psychopharmacology·A EttenbergT D Geist
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·R Ciccocioppo
Jun 12, 1999·The American Journal on Addictions·F R LevinE V Nunes
Jul 8, 1999·Biological Psychiatry·J P McEvoyW H Wilson
Jun 1, 2000·Journal of Clinical Psychopharmacology·J GrabowskiR Bailey
Sep 28, 2000·The Journal of Pharmacy and Pharmacology·M P Arolfo, B A McMillen
Mar 29, 2001·Psychiatric Services : a Journal of the American Psychiatric Association·D L NoordsyH Xie
Jul 27, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G A WiesbeckJ Boening
Aug 18, 2001·European Addiction Research·M G Monteiro
Aug 25, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·B ScattonR Porsolt
Oct 6, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D Naber, A Karow
Oct 3, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·David A SmelsonDouglas Ziedonis
Dec 31, 2002·Schizophrenia Research·Alan I GreenRael D Strous
May 22, 2003·Drug and Alcohol Dependence·Kyle M KampmanCharles P O'Brien
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John GrabowskiJoy Schmitz
Apr 3, 2004·Nature Reviews. Drug Discovery·Bryan L RothWesley K Kroeze
May 7, 2004·Psychiatric Services : a Journal of the American Psychiatric Association·Jose de Leon
May 29, 2004·Alcoholism, Clinical and Experimental Research·José GuardiaMiguel Casas
Jun 17, 2004·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Lieuwe de HaanDon Linszen
Oct 21, 2004·Journal of Psychosocial Nursing and Mental Health Services·Lois K Evans, Neville E Strumpf
May 28, 2005·The Journal of Nervous and Mental Disease·Steven L SayersStanley N Caroff
Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jose de LeonGeorge M Simpson
Jul 12, 2005·Drug and Alcohol Dependence·Krisztina Gál, István Gyertyán
Jul 26, 2005·European Archives of Psychiatry and Clinical Neuroscience·Miriam BottlenderMichael Soyka
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kent E HutchisonRobert Swift

❮ Previous
Next ❯

Citations

Dec 5, 2015·Expert Opinion on Pharmacotherapy·Jean-Michel AzorinRaoul Belzeaux
Jan 17, 2012·The American Journal of Drug and Alcohol Abuse·Kristiina KivimiesJari Tiihonen
Nov 14, 2014·Journal of Dual Diagnosis·Yilang TangRobert O Cotes
Oct 30, 2015·Journal of Psychopharmacology·Robin P Wilson, Sagnik Bhattacharyya
May 12, 2019·Bipolar Disorders·Alexandria S ColesTony P George
Mar 31, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
Oct 12, 2019·Acta Psychiatrica Scandinavica·J M Rubio, J M Kane
Jan 7, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brenda Cabrera-MendozaHumberto Nicolini
Mar 19, 2021·Journal of Clinical Psychopharmacology·Louis-David LeclercMarc-André Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Clinical Psychology Review
Lynsey GreggGillian Haddock
Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors
P J ConrodM Dongier
© 2021 Meta ULC. All rights reserved