Abstract
Heat shock proteins act as intracellular chaperones by assisting with proper protein folding in response to various cellular stresses. In doing so, these proteins protect the cell from unwanted protein aggregation, which in turn, plays an important role in the pathogenesis of numerous disorders. Previous reports from our laboratory have described a 40 kDa catecholamine regulated heat shock-like protein (CRP40), an alternate gene product of the 70 kDa mitochondrial heat shock protein, mortalin. CRP40 shares an intimate association with dopaminergic activity, specifically as it pertains to dopamine dysregulation in schizophrenia. This study investigates human CRP40/mortalin mRNA expression within dorsolateral prefrontal cortex postmortem specimens from normal control, schizophrenic and bipolar patients obtained from the Stanley Medical Research Institute. Real-time polymerase chain reaction was carried out for all patient samples (n=105; n=35 per group) in a blinded manner. No significant alterations in CRP40/mortalin mRNA expression levels were observed between control, bipolar and schizophrenic patients. However, multiple regression demonstrated a distinct positive correlation between CRP40/mortalin mRNA expression and lifetime...Continue Reading
References
Aug 1, 1988·Trends in Neurosciences·D R Weinberger
Jan 1, 1993·Journal of Molecular Neuroscience : MN·G M RossR K Mishra
Mar 28, 1996·European Journal of Pharmacology·P I ModiR K Mishra
Mar 17, 2000·Brain Research. Brain Research Reviews·F M Benes
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·P Seeman, S Kapur
Oct 29, 2000·Cerebral Cortex·J H CallicottD R Weinberger
Feb 22, 2001·Journal of Neurochemistry·V D Nair, R K Mishra
Dec 18, 2001·Biological Psychiatry·D R WeinbergerT E Goldberg
Nov 8, 2002·Synapse·Niki SharanEliot L Gardner
Aug 29, 2003·Current Molecular Medicine·L D Selemon, G Rajkowska
Oct 28, 2004·European Journal of Pharmacology·Luigi PiraLuca Pani
Feb 8, 2005·Schizophrenia Research·Joseph P GabrieleRam K Mishra
Jun 5, 2007·Biological Psychiatry·David C GlahnDawn I Velligan
Mar 13, 2009·Cell Stress & Chaperones·Joseph GabrieleRam K Mishra
Apr 1, 2009·Neurobiology of Disease·Victor S Van LaarTeresa G Hastings