Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.

Neuropharmacology
Jenny L WileyLaura J Sim-Selley

Abstract

Dysregulation of the endocannabinoid and dopamine systems has been implicated in schizophrenia. The purpose of this study was to examine the effects of sub-chronic treatment with two antipsychotics on CB1 receptor-mediated in vitro and in vivo effects. Adult and adolescent male and female rats were injected twice daily with haloperidol (0.3 mg/kg), clozapine (10 mg/kg), or saline for 10 days. Subsequently, CB1 receptor number and function were assessed by [3H]SR141716 and WIN55,212-2-stimulated [35S]GTPgammaS binding, respectively. The effects of sub-chronic antipsychotic treatment on the in vivo actions of Delta9-tetrahydrocannabinol (Delta9-THC) were also evaluated. In adult female rats, antipsychotic treatment attenuated maximal stimulation of CB1 receptor-mediated G-protein activity in the striatum (clozapine) and prefrontal cortex (both antipsychotics), but not in the ventral midbrain. Associated changes in CB1 receptor number were not observed, suggesting that this attenuation was not due to downregulation. In vivo, sub-chronic treatment with clozapine, but not haloperidol, attenuated Delta9-THC-induced suppression of activity in adult females, whereas neither drug altered hypothermia or catalepsy. In contrast, antipsycho...Continue Reading

References

Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·B R MartinS J Ward
Aug 1, 1993·Brain Research. Molecular Brain Research·R E SeeP W Kalivas
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·J P MeschlerA C Howlett
Jun 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Sachin PatelCecilia J Hillard
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam MelisGian Luigi Gessa
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Katerina ZavitsanouXu Feng Huang
Sep 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea GiuffridaDaniele Piomelli
Jul 5, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Suresh SundramBrian Dean
Jul 16, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Anton GrechRobin M Murray
Mar 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R G Pertwee

❮ Previous
Next ❯

Citations

Jul 25, 2009·Psychopharmacology·Emilio Fernandez-EspejoFernando Rodriguez de Fonseca
Jun 18, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen M EgganDavid A Lewis
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria S DaltonKaterina Zavitsanou
Aug 3, 2010·Psychiatry Research·Arpana AgrawalUNKNOWN Bipolar Genome Study
May 22, 2009·Journal of Neurochemistry·Jana Sánchez-WandelmerRebeca Busto
Jun 23, 2011·Human Psychopharmacology·Young-Min ParkHeon-Jeong Lee
Nov 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zoltan MakkosJudit Lazary
Jul 18, 2016·Pharmacology, Biochemistry, and Behavior·Doodipala Samba Reddy
Apr 16, 2009·International Review of Psychiatry·Chris S Breivogel, Laura J Sim-Selley
Nov 15, 2016·Nature Nanotechnology·Akane FurutaKen'ya Furuta
Oct 21, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Faith BorganOliver Howes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.