Antipsychotic-like effects of zolpidem in Wistar rats

European Journal of Pharmacology
Pawel MierzejewskiPrzemyslaw Bienkowski

Abstract

Aside from their use in the treatment of anxiety disorders and insomnia, benzodiazepines and other GABAA receptor positive modulators are widely used as add-on treatments in schizophrenic and non-schizophrenic psychoses. However, there is relatively little direct clinical or pre-clinical evidence for antipsychotic effects of GABAergic medications. Previous studies have indicated that zolpidem, a GABAergic drug acting preferentially at α1-containing GABAA receptors, may produce catalepsy through interactions with dopaminergic neurotransmission. The aim of the present study was to investigate effects of zolpidem in experimental models of antipsychotic activity and extrapyramidal side effects in Wistar rats. Effects of zolpidem were compared with that of a classic benzodiazepine drug, diazepam and a second-generation antipsychotic medication, risperidone. High doses of risperidone (10.0mg/kg, i.p.) and zolpidem (10.0mg/kg, i.p.), but not diazepam, induced relatively short-lasting cataleptic responses in the bar test. Zolpidem and risperidone, but not diazepam, produced some antipsychotic-like effects at doses, which produced no catalepsy and did not inhibit spontaneous locomotor activity and apomorphine-induced stereotypies. The p...Continue Reading

References

Mar 1, 1992·Archives of General Psychiatry·D L BraffM A Geyer
Feb 1, 1990·Archives of General Psychiatry·D L Braff, M A Geyer
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mark A Geyer, Bart Ellenbroek
Mar 18, 2004·Experimental Neurology·Lei ChenWing-Ho Yung
Feb 1, 2005·Psychiatry and Clinical Neurosciences·Tiao-Lai Huang
Dec 3, 2008·The American Journal of Psychiatry·Schahram Akbarian
Nov 28, 2009·Journal of Psychopharmacology·David J Nutt, S M Stahl
Jan 22, 2010·Journal of Neurochemistry·Emma Perez-CostasRosalinda C Roberts
Feb 2, 2010·The Australian and New Zealand Journal of Psychiatry·Geoffrey Yuet Mun WongRohan Dhillon
Apr 19, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Albert AcewiczPrzemyslaw Bienkowski
Jan 1, 2005·Current Neuropharmacology·David W Volk, David A Lewis
May 9, 2012·Expert Opinion on Drug Safety·Juan A GallegoChristoph U Correll
Oct 19, 2013·Neuroscience Letters·Pawel MierzejewskiPrzemyslaw Bienkowski
May 3, 2014·Pharmacology, Biochemistry, and Behavior·Albert AcewiczPrzemyslaw Bienkowski
Jul 23, 2014·Journal of Psychopharmacology·Faye SimMaxine X Patel

❮ Previous
Next ❯

Citations

Sep 7, 2016·European Journal of Medicinal Chemistry·Monika MarcinkowskaPrzemyslaw Bienkowski
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikola FajkisMarcin Kolaczkowski
Nov 6, 2021·Pharmacological Reports : PR·Camila de Oliveira PachecoSandra Elisa Haas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.