Antipsychotic polypharmacy in a regional health service: a population-based study.

BMC Psychiatry
Miguel BernardoAntoni Serrano-Blanco

Abstract

To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain), focusing on the use of clozapine and long-acting injections (LAI). Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA) from the Anatomical Therapeutic Chemical classification (ATC) code N05A (except lithium) were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9%) corresponded to an antipsychotic combination, 47,386 (66.7%) to monotherapy and 13,763 (19.4%) to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1%) and oral risperidone (36.4%) were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8%) revealed 198 different combin...Continue Reading

References

Oct 1, 1994·The American Journal of Psychiatry·J D HegartyG Oepen
Jan 2, 2003·Psychiatric Services : a Journal of the American Psychiatric Association·Andre TappNael Kilzieh
Jul 5, 2003·The Annals of Pharmacotherapy·Jennifer E SchumacherHolly R Griffin
Mar 3, 2004·The American Journal of Psychiatry·Delbert G RobinsonRobert M Bilder
May 4, 2004·The Journal of Clinical Psychiatry·Alexander L MillerBernardo Tarin-Godoy
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanUNKNOWN Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Jan 5, 2006·The American Journal of Psychiatry·Thomas R Insel
Mar 18, 2006·Acta Psychiatrica Scandinavica. Supplementum·G SmithR Balshaw
Apr 25, 2006·Schizophrenia Research·Julie KreyenbuhlFrederic C Blow
Jun 30, 2006·Administration and Policy in Mental Health·Thomas UttaroLawrence Shindelman
Oct 31, 2006·Schizophrenia Research·Christoph U CorrellPeter Manu
Apr 7, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Julie A KreyenbuhlFrederic C Blow
Jul 3, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Julie KreyenbuhlMark Olfson
Jul 3, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Todd P GilmerDilip V Jeste
Aug 8, 2007·Psychiatry Research·Judith UsallUNKNOWN SOHO Study Group
Oct 27, 2007·Pharmacoepidemiology and Drug Safety·Nevena DivacMilica Prostran
Dec 7, 2007·The Journal of Clinical Psychiatry·Troy A MooreAlexander L Miller
Dec 22, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Constantin TranulisEmmanuel Stip
Mar 5, 2008·The American Journal of Psychiatry·Monica HazraGary Remington
Apr 26, 2008·Schizophrenia Bulletin·Corrado BarbuiAndrea Cipriani
Aug 7, 2008·The Annals of Pharmacotherapy·Min YangCynthia A Mascarenas
Dec 4, 2008·Clinical Neuropharmacology·Ivan Lerma-CarrilloEnrique Baca-García
Dec 6, 2008·Journal of Psychiatric Practice·Anand K Pandurangi, Alican Dalkilic
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Andrea CiprianiCorrado Barbui
Jul 16, 2009·Current Medical Research and Opinion·Jamie KaragianisRuth Dickson
Jan 6, 2010·Archives of General Psychiatry·Ramin Mojtabai, Mark Olfson
Jan 9, 2010·Journal of Clinical Pharmacology·Nadezda RancevaDeji Odelola

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Citations

Oct 16, 2014·Indian Journal of Psychiatry·Sandeep GroverKamla Deka
Oct 29, 2015·The International Journal of Neuropsychopharmacology·Miquel BioqueUNKNOWN PEPs GROUP
Apr 4, 2015·International Journal of Psychiatry in Medicine·Carlo PiccinniFabrizio de Ponti
Mar 7, 2018·Journal of Psychiatric Practice·Nuria Berrocal-IzquierdoMiguel Bernardo
Feb 7, 2019·Pharmacoepidemiology and Drug Safety·Courtney BakerPaul M Bakaki
Oct 31, 2017·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Esra YaziciAtila Erol
Dec 15, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Julaeha JulaehaAndi Hermansyah
Oct 19, 2016·International Clinical Psychopharmacology·Nuria Berrocal-IzquierdoMiguel Bernardo
Oct 21, 2016·Clinical Neuropharmacology·Gianna SepedeMassimo Di Giannantonio
May 26, 2017·Cadernos de saúde pública·Juliana de Oliveira CostaMark Drew Crosland Guimarães
Jan 8, 2021·Comprehensive Child and Adolescent Nursing·Wipada SangnimitchaikulSigrid Ladores
Jul 1, 2021·Scientific Reports·Verónica GamónGabriel Sanfélix-Gimeno

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Methods Mentioned

BETA
SGA

Software Mentioned

Visual Basic for Applications ( VBA )
STAR
Psychiatric Clinical Knowledge Enhancement System ( PSYCKES )

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