Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine

Journal of Psychiatric Practice
Danielle K StrackJonathan M Meyer

Abstract

The goal of this study was to examine provider prescribing habits following carbamazepine discontinuation and to assess for the presence of antipsychotic-related adverse drug reactions due to the loss of car-bamazepine-related induction of the cytochrome P450 enzyme (CYP) 3A4 and p-glycoprotein. A retrospective chart review of patient records from January 2006 through December 2007 at the Veterans Affairs (VA) San Diego Healthcare System was done, which focused on the co-prescription of carbamazepine and a second-generation (atypical) antipsychotic (aripiprazole, quetiapine, risperidone) that is significantly affected by CYP3A4/p-glycoprotein induction. The cases in which carbamazepine was discontinued while the antipsychotic was continued during the 2-year time frame were then analyzed further. Data were collected concerning documentation of antipsychotic-related adverse drug reactions that occurred after carbamazepine was discontinued and prescribers' responses to carbamazepine discontinuation. Nine patients were identified who had concomitant prescriptions for carbamazepine and a second-generation antipsychotic and who then discontinued carbamazepine. In only one case did the provider initially decrease the dose of the antip...Continue Reading

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Sep 29, 2012·Epilepsia·Martin J BrodieDieter Schmidt
Oct 15, 2011·Journal of Pharmaceutical and Biomedical Analysis·Yin WuAidong Wen
Jul 2, 2010·Perspectives in Psychiatric Care·Norman L Keltner, Randy L Moore
Mar 31, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A FernandezS Thümmler
May 20, 2017·CNS Drugs·Martin J Brodie
Aug 9, 2017·Expert Review of Neurotherapeutics·Pavel Klein, Dwain Tolbert
Nov 5, 2016·Journal of Clinical Psychopharmacology·Georgios SchoretsanitisMichael Paulzen

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