Antipsychotic Prescriptions Among Adults With Major Depressive Disorder in Office-Based Outpatient Settings: National Trends From 2006 to 2015

The Journal of Clinical Psychiatry
Taeho Greg RheeRobert A Rosenheck

Abstract

A recent moderately long-term study found an antipsychotic to be more effective than an antidepressant as the next-step treatment of unresponsive major depressive disorder (MDD). It is thus timely to examine recent trends in the pharmacoepidemiology of antipsychotic treatment of MDD. Data from the 2006-2015 National Ambulatory Medical Care Survey, nationally representative samples of office-based outpatient visits in adults with MDD (ICD-9-CM codes 296.20-296.26 and 296.30-296.36) (n = 4,044 unweighted), were used to estimate rates of antipsychotic prescribing over these 10 years. Multivariable logistic regression analysis identified demographic and clinical factors independently associated with antipsychotic use in MDD. Antipsychotic prescribing for MDD increased from 18.5% in 2006-2007 to 24.9% in 2008-2009 and then declined to 18.9% in 2014-2015. Visits with adults 75 years or older showed the greatest decline from 27.0% in 2006-2007 to 10.7% in 2014-2015 (OR for overall trend = 0.73; 95% CI, 0.56-0.95). The most commonly prescribed antipsychotic agents were aripiprazole, olanzapine, quetiapine, and risperidone. Antipsychotic prescription was associated with being black or Hispanic, having Medicare among adults under 65 year...Continue Reading

Citations

Dec 19, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Taeho Greg Rhee
May 1, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Mohsen BazarganShervin Assari
Oct 7, 2019·Journal of Clinical Pharmacy and Therapeutics·Caterina PalleriaEmilio Russo
Oct 1, 2020·PloS One·Tobias GerhardMark Olfson
Mar 14, 2019·Journal of Mental Health·Jone BjornestadMarius Veseth
Apr 30, 2020·Drugs·Gin S MalhiAmber Hamilton
Jan 24, 2021·The Science of the Total Environment·J EscuderoU Lertxundi
Sep 3, 2019·Chemical Research in Toxicology·Adam M SpeenIlona Jaspers

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