Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions: A Cohort Study

Journal of the American Geriatrics Society
Shoshana J HerzigEdward R Marcantonio

Abstract

Off-label use of antipsychotics is common in hospitals, most often for delirium management. Antipsychotics have been associated with aspiration pneumonia in community and nursing home settings, but the association in hospitalized individuals is unexplored. We aimed to investigate the association between antipsychotic exposure and aspiration pneumonia during hospitalization. Retrospective cohort study. Large academic medical center. All adult hospitalizations between January 2007 and July 2013. We excluded outside hospital transfers, hospitalizations shorter than 48 hours, and psychiatric hospitalizations. Antipsychotic use defined as any pharmacy charge for an antipsychotic medication. Aspiration pneumonia was defined according to a discharge diagnosis code for aspiration pneumonia not present on admission and validated using chart review. A generalized estimating equation was used to control for 43 potential confounders. Our cohort included 146,552 hospitalizations (median age 56; 39% male). Antipsychotics were used in 10,377 (7.1%) hospitalizations (80% atypical, 35% typical, 15% both). Aspiration pneumonia occurred in 557 (0.4%) hospitalizations. The incidence of aspiration pneumonia was 0.3% in unexposed individuals and 1.2...Continue Reading

References

Oct 1, 1990·The American Journal of Medicine·G A HarknessK J Roghmann
Feb 12, 1987·The New England Journal of Medicine·W A RayL J Melton
Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Jan 27, 1999·Journal of the American Geriatrics Society·R M LeipzigM E Tinetti
Jun 12, 1999·Journal of the American Geriatrics Society·B M PsatyC D Furberg
Feb 15, 2002·Journal of the American Geriatrics Society·P S WangJ Avorn
Jan 28, 2005·Journal of the American Geriatrics Society·Sharon K InouyeJoseph V Agostini
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
Dec 2, 2005·The New England Journal of Medicine·Philip S WangM Alan Brookhart
Feb 13, 2008·Journal of the American Geriatrics Society·Wilma KnolAntoine C G Egberts
Sep 17, 2008·Journal of Clinical Psychopharmacology·James L RudolphRegina E McGlinchey
Jan 16, 2009·The New England Journal of Medicine·Wayne A RayC Michael Stein
Apr 7, 2010·Annals of Internal Medicine·Gianluca TrifiròMiriam C J M Sturkenboom
Jul 8, 2010·BMC Geriatrics·Jen-Tzer GauTzu-Cheg Kao
Oct 5, 2010·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Kristina StarI Ralph Edwards
Dec 7, 2011·Journal of the American Geriatrics Society·Joseph H FlahertyBirong Dong
Apr 4, 2013·The Annals of Pharmacotherapy·Rajender R AparasuHua Chen
Oct 7, 2014·The Lancet. Psychiatry·Sharon K InouyeEran D Metzger
Oct 28, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Kah Poh LohTara Lagu
May 29, 2015·Pharmacoepidemiology and Drug Safety·Michela NosèCorrado Barbui
Feb 20, 2016·Journal of the American Geriatrics Society·Shoshana J HerzigEdward R Marcantonio
Mar 24, 2016·Journal of the American Geriatrics Society·Karin J NeufeldDale M Needham
May 1, 2016·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Shoshana J HerzigEdward R Marcantonio
Mar 25, 2017·Age and Ageing·Victoria EwanJohn Simpson

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Citations

Nov 3, 2017·Journal of the American Geriatrics Society·James L Rudolph
Jan 25, 2019·Current Opinion in Infectious Diseases·Sarah Neill, Nathan Dean
Sep 3, 2019·Annals of Internal Medicine·Edward R Marcantonio
Sep 14, 2019·Expert Review of Clinical Pharmacology·Abraham E Rodriguez, Marcos I Restrepo
Nov 20, 2019·Journal of the American Geriatrics Society·Matthew BasciottaShoshana J Herzig
Feb 15, 2019·The New England Journal of Medicine·Lionel A Mandell, Michael S Niederman
Mar 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O D OstroumovaA P Pereverzev
Oct 30, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Paula D StrassleDavid J Weber
Feb 29, 2020·Drugs & Aging·Blair RajamakiAnna-Maija Tolppanen
Mar 22, 2019·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Amit K PahwaEthan Cumbler
Oct 6, 2020·Annals of Internal Medicine·Melissa L P Mattison
Apr 14, 2020·Journal of the American Medical Directors Association·Aaron M OgletreeDeborah Perfetto
Oct 8, 2021·Seminars in Neurology·Sophia L Ryan, Eyal Y Kimchi

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