Antipsychotics and the risk of sudden cardiac death

Archives of Internal Medicine
Sabine M J M StrausBruno H C Stricker

Abstract

Antipsychotics have been associated with prolongation of the corrected QT interval and sudden cardiac death. Only a few epidemiological studies have investigated this association. We performed a case-control study to investigate the association between use of antipsychotics and sudden cardiac death in a well-defined community-dwelling population. We performed a population-based case-control study in the Integrated Primary Care Information (IPCI) project, a longitudinal observational database with complete medical records from 150 general practitioners. All instances of death between January 1, 1995, and April 1, 2001, were reviewed. Sudden cardiac death was classified based on time between onset of cardiovascular symptoms and death. For each case, up to 10 random controls were matched for age, sex, date of sudden death, and practice. Exposure at the index date was categorized as 3 mutually exclusive groups of current use, past use, and nonuse. The study population comprised 554 cases of sudden cardiac death. Current use of antipsychotics was associated with a 3-fold increase in risk of sudden cardiac death. The risk of sudden cardiac death was highest among those using butyrophenone antipsychotics, those with a defined daily do...Continue Reading

Citations

Jul 29, 2005·Journal of the American Medical Informatics Association : JAMIA·Georgio MosisMiriam C J M Sturkenboom
May 5, 2007·Annals of General Psychiatry·Jadranka Culav SumićVlado Jukić
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Alex F ManiniLewis S Nelson
Jan 16, 2009·The New England Journal of Medicine·Wayne A RayC Michael Stein
Oct 1, 2011·PloS One·Marieke T BlomHanno L Tan
Nov 1, 2006·Current Neurology and Neuroscience Reports·Philip S WangSebastian Schneeweiss
Oct 24, 2012·European Heart Journal·Elijah R Behr, Dan Roden
Apr 25, 2006·Journal of Clinical Psychopharmacology·Mitchell J BarnettPeter J Kaboli
Feb 3, 2007·Expert Opinion on Drug Metabolism & Toxicology·Pedro DoradoAdrián Llerena
Mar 10, 2016·Asian Journal of Psychiatry·Muhammad Chanchal AzadTanvir Chowdhury Turin
Sep 26, 2015·Acta Psychiatrica Scandinavica·S MaceD Taylor
Jan 9, 2013·Psychosomatics·Scott R BeachJeff C Huffman
Sep 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A BirkhoferG Schmidt
Oct 12, 2012·Asian Journal of Psychiatry·Fariba RajabiNarges Beyraghi
Jan 26, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Connie MarrasPaula A Rochon
Apr 29, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Min Ahn
Jan 19, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuji OzekiHiroshi Kunugi
Feb 10, 2010·Journal of the American Medical Directors Association·Jessica J JalbertKate L Lapane
Aug 4, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Murat EmulIbrahim Keles
Jul 25, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Fulvio A ScorzaWagner F Gattaz
Jun 16, 2009·Schizophrenia Research·Stefan WeinmannVolkmar Aderhold
Jun 27, 2006·Child and Adolescent Psychiatric Clinics of North America·Frederick J StoddardAnnah N Abrams
Nov 18, 2009·British Journal of Clinical Pharmacology·Kate JollyMichael J S Langman
Feb 13, 2008·Journal of the American Geriatrics Society·Wilma KnolAntoine C G Egberts
Apr 26, 2006·Diabetes, Obesity & Metabolism·David S H Bell
Jul 28, 2006·British Journal of Clinical Pharmacology·Marie L De BruinArno W Hoes
Aug 12, 2008·Journal of the American Geriatrics Society·Soko SetoguchiSebastian Schneeweiss
Feb 5, 2008·Acta Psychiatrica Scandinavica·H KoponenJ Veijola
Jul 22, 2010·Journal of Mass Spectrometry : JMS·Eva SaarJochen Beyer
Mar 19, 2016·Epidemiology and Psychiatric Sciences·J SultanaG Trifiró
Dec 24, 2009·Pharmacoepidemiology and Drug Safety·Cecilia P ChungWayne A Ray
Oct 18, 2005·Forensic Science International : Synergy·R J FlanaganL Dunk
Jan 18, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·D BelhaniQ Timour
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Steffen SchulzAndreas Voss
Jul 27, 2015·Schizophrenia Research·Ping-Yi HouChian-Jue Kuo
Oct 1, 2005·International Review of Psychiatry·Silvio Garattini, Vittorio Bertele'
Apr 9, 2013·International Journal of Psychiatry in Clinical Practice·Narges BeyraghiFarhad Hajsheikholeslami
Aug 24, 2006·Expert Opinion on Pharmacotherapy·Barrat Luft, David Taylor

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