Antipsychotics, dopamine D₂ receptor occupancy and clinical improvement in schizophrenia: a meta-analysis

Schizophrenia Research
Zeynep YilmazZafiris J Daskalakis

Abstract

Treatment of schizophrenia (SCZ) was revolutionized with the development of the antipsychotic medications. Although imaging studies have linked antipsychotic D₂ receptor occupancy and clinical response in SCZ, heterogeneity between cohorts and methods has made it challenging to generalize findings across studies. The main objective of this meta-analysis was to analyze the relationship between in vivo estimation of typical and atypical antipsychotic D₂ receptor occupancy and treatment response in SCZ. Using the keywords "dopamine D₂ receptor occupancy," "schizophrenia," "PET/SPECT" and "antipsychotics," and further refining our search to journal articles with information on % striatal D₂ occupancy and % change in clinical symptoms as indexed by either the BPRS or the PANSS, our final analysis consisted of 16 imaging studies (20 cohorts; N=206). The first step of the meta-analysis confirmed the positive relationship between antipsychotic medication and clinical improvement in SCZ (ES=1.36; 95% CI: 1.13-1.60). The second step of our analysis revealed that when D₂ occupancy was limited to less than 80% in order to control for the appearance of extrapyramidal symptoms, high D₂ occupancy was correlated with reduction in clinical scor...Continue Reading

References

May 1, 1997·International Clinical Psychopharmacology·B ScattonH Schoemaker
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Abi-DarghamM Laruelle
Nov 26, 2002·The Journal of Clinical Psychiatry·Sitra Tauscher-WisniewskiRobert B Zipursky
Jan 25, 2003·Journal of Clinical Psychopharmacology·Rodrigo A BressanLyn S Pilowsky
Sep 11, 2004·Journal of Psychopharmacology·Rosa Maria MorescoFerruccio Fazio
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Iluminada CorripioEnric Alvarez
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanClinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Feb 7, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adriano B L TortDiogo R Lara
Nov 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ofer AgidShitij Kapur
Jan 3, 2007·Archives of General Psychiatry·Jonna PeräläJouko Lönnqvist
Apr 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David C MamoDavid McDonnell
Sep 4, 2008·Expert Opinion on Emerging Drugs·Ofer AgidGary Remington
Feb 24, 2009·NeuroImage·A M CatafauBarcelona Clinical Imaging in Psychiatry Group
Jul 11, 2009·Expert Opinion on Investigational Drugs·Robin Emsley
Aug 25, 2009·Lancet·Jim van Os, Shitij Kapur
Jan 7, 2010·Current Opinion in Psychiatry·Mathias ZinkAndreas Meyer-Lindenberg
Apr 12, 2011·CNS Drugs·Thomas R E Barnes, Carol Paton
Oct 29, 2011·Annals of the New York Academy of Sciences·Stephen R MarderMichelle Solis
Feb 3, 2012·Journal of Psychiatry & Neuroscience : JPN·Paolo Fusar-PoliStefan Borgwardt

Citations

Feb 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Bay-RichterP M Moran
Jan 1, 2013·Journal of Molecular Psychiatry·Melkaye G MelkaShiva M Singh
Jan 16, 2014·The International Journal of Neuropsychopharmacology·Timm B PoepplMichael Landgrebe
Mar 18, 2016·Qualitative Health Research·Gabrielle Le GeytGillian Haddock
Jul 13, 2017·Expert Review of Clinical Pharmacology·Georgios SchoretsanitisJose de Leon
Feb 6, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Judith M GaultAviva Abosch
Dec 16, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Judith M GaultAviva Abosch
Mar 24, 2020·Molecular Psychiatry·Pramod C NairTarun Bastiampillai

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