PMID: 7356888Jan 1, 1980Paper

Antipyrine elimination by patients under treatment with monoamine oxidase inhibitors

British Journal of Clinical Pharmacology
S E SmithP J Tyrer


1 Antipyrine elimination kinetics have been determined in fifteen patients before and after 4 weeks treatment with monoamine oxidase inhibitors and in five patients after treatment only. 2 Antipyrine elimination was slightly but significantly slowed by 28 days treatment with phenelzine but the degree of slowing was uninfluenced by acetylator phenotype or dosage of phenelzine administered. 3 The findings suggest that at the dosage used phenelzine is a weak inhibitor of hepatic microsomal mixed function oxidase in man and it is concluded that this is likely to provide an important source of drug interaction in some patients.


Jun 1, 1977·British Journal of Clinical Pharmacology·I H Stevenson
Aug 26, 1972·British Medical Journal·H Schröder
Jul 1, 1969·British Journal of Pharmacology·K J Rogers, J A Thornton

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Feb 16, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mee-Sook SongGlen B Baker
Oct 1, 1981·The Journal of Pharmacy and Pharmacology·P DostertN Sontag

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