Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation.

Archives of Biochemistry and Biophysics
A Z ReznickL Packer

Abstract

L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion. However, the mechanism of protection is unknown. The two dominating hypotheses are: (i) L-propionyl carnitine can serve as an energy source for heart muscle cells by being enzymatically converted to propionyl-CoA and subsequently utilized in the Krebs cycle (a metabolic hypothesis), and (ii) it can act as an antiradical agent, protecting myocardial cells from oxidative damage (a free radical hypothesis). To test the two possible pathways, we compared the protection afforded to the ischemia-reperfused hearts by L-propionyl carnitine and its optical isomer, D-propionyl carnitine. The latter cannot be enzymatically utilized as an energy source. The Langendorff perfusion technique was used and the hearts were subjected to 40 min of ischemia and 20 min of reperfusion. In analysis of ischemia-reperfused hearts, a strong correlation was found between the recovery of mechanical function and the presence of protein oxidation products (protein carbonyls). Both propionyl carnitines efficiently prevented protein oxidation but L-propionyl carnitine-perfused hearts had two times greater left ventricular d...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·H NohlT Ishikawa
Jan 1, 1990·Free Radical Biology & Medicine·S R Powell, D Hall
Jan 1, 1990·Free Radical Research Communications·A ArduiniG Federici
Jun 1, 1987·Journal of Cardiovascular Pharmacology·D J Hearse, A Tosaki
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R BolliP B McCay
Dec 29, 1989·Biochemical and Biophysical Research Communications·D K DasP S Rao
Dec 1, 1989·Archives of Biochemistry and Biophysics·P E Starke-Reed, C N Oliver
Jan 1, 1989·Free Radical Research Communications·J P Kehrer
Jun 24, 1989·Molecular and Cellular Biochemistry·R FerrariO Visioli
Jan 1, 1988·Basic Research in Cardiology·L DeMaisonA Eggleston
Feb 1, 1988·Pharmacological Research Communications·R FerrariO Visioli
Aug 1, 1980·Journal of Molecular and Cellular Cardiology·C GuarnieriC M Caldarera

❮ Previous
Next ❯

Citations

Aug 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ibrahim KocerKorkmaz Serifoglu
Jul 17, 2008·Biogerontology·Thilakavathy ThangasamyPanneerselvam Chinnakannu
Apr 28, 2009·Biological Trace Element Research·Nurhan GumralManuel F Flores-Arce
Oct 1, 1993·Trends in Pharmacological Sciences·I B Fritz, E Arrigoni-Martelli
Jan 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A CarusoM Amico-Roxas
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sethumadhavan SavithaChinnakannu Panneerselvam
Aug 15, 2002·Archives of Biochemistry and Biophysics·BaoJun ChangMasayasu Inoue
Dec 24, 1997·Progress in Cardiovascular Diseases·M A Arsenian
Jun 25, 1999·Free Radical Biology & Medicine·X LuoD C Lehotay
May 31, 2001·The Journal of Nutritional Biochemistry·A DayanandanC Panneerselvam
Dec 24, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Serdar AkgunAydin Sav
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hossam M M Arafa, Mohamed M Sayed-Ahmed
Jan 1, 1995·Critical Reviews in Food Science and Nutrition·D R Janero
Mar 23, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P Juliet Arockia Rani, C Panneerselvam
Jan 13, 2006·The Journal of Cardiovascular Nursing·Barry S Kendler
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·Abdulhakeem A Al-MajedOthman A Al-Shabanah
Oct 19, 2007·Clinical and Experimental Pharmacology & Physiology·K BalasaraswathiC V Anuradha
Dec 21, 2007·Diabetes, Obesity & Metabolism·P RajasekarC V Anuradha
Dec 23, 2011·Oxidative Medicine and Cellular Longevity·B Poljsak
Oct 24, 2002·Biological & Pharmaceutical Bulletin·Satoshi WatanabeTetsuya Fukui
Jul 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Tatsujiro OkaKenji Hamaoka
Apr 28, 2011·Nutrition Reviews·Carmen MingoranceMaria Alvarez de Sotomayor
Nov 27, 2015·Journal of Immunological Methods·Rabab M Abou El-MagdDavid S Wishart
Jan 27, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Graziela S RibasCarmen R Vargas
Dec 2, 2008·Neurological Research·Prem KumarAnjali Rao
Jan 1, 2011·Saudi Journal of Biological Sciences·Hind Abdullah Seed Alzahrani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.