Antireflux surgery does not change ongoing renal functional deterioration

Renal Failure
Seçil Arslansoyu ÇamlarSalih Kavukçu

Abstract

Treatment modalities of vesicoureteral reflux (VUR) consist of antimicrobial prophylaxis and antireflux surgery. In this study, we aimed to determine if antireflux surgery changes the course of renal functional deterioration in children with VUR and urinary tract infections (UTI). Medical files of patients with VUR diagnosed during evaluation for UTI were evaluated retrospectively for gender, age, follow-up period, and renal ultrasonography (US) and serial 99mTc-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy findings. Estimated glomerular filtration rate and urinary protein levels were determined at the initial and last visits, and before the operation in children who had antireflux surgery. The patients were divided into two groups as solely medically treated (Group 1) and both medically and surgically treated (Group 2). Group 2 was further divided as those with stable renal function (Group 2a) and with progressive renal injury (Group 2b). There were 140 patients (77 female; mean age 51.6 ± 51.9 months). Group 1 and Group 2 included 82 and 58 patients, respectively. In Group 2, the number of patients with the abnormal US, DMSA scintigraphy, and renal function was higher than in Group 1. Recurrent UTI rate was similar, but p...Continue Reading

References

Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N P Goldraich, I H Goldraich
Jul 24, 2003·Archives of Disease in Childhood·D WheelerJ C Craig
Oct 3, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hermann OlbingHildegard Lax
Nov 9, 2004·Lancet·Vassilios Fanos, Luigi Cataldi
Mar 28, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ulf JodalPeter F Hoyer
Jun 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Malcolm G Coulthard
Jul 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alper SoyluSalih Kavukçu
Aug 29, 2014·Lancet·Kjell Tullus
Jan 7, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tej K MattooUNKNOWN RIVUR Trial Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Indian Journal of Pediatrics
Ljiljana JaukovićZoran Krstić
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Grazyna KrzemieńKrzysztof Toth
Vojnosanitetski pregled. Military-medical and pharmaceutical review
Boris AjdinovićLjiljana Jauković
© 2022 Meta ULC. All rights reserved