Antiretroviral adherence and virologic suppression in partnered and unpartnered HIV-positive individuals in southern Brazil

PloS One
Marineide Gonçalves de MeloK Nielsen-Saines

Abstract

An undetectable serum HIV-1 load is key to effectiveness of antiretroviral (ARV) therapy, which depends on adherence to treatment. We evaluated factors possibly associated with ARV adherence and virologic response in HIV-infected heterosexual individuals. A cross-sectional study was conducted in 200 HIV-1 serodiscordant couples and 100 unpartnered individuals receiving ARV treatment at a tertiary hospital in southern Brazil. All subjects provided written informed consent, answered demographic/behavioral questionnaires through audio computer-assisted self-interviews (ACASI), and collected blood and vaginal samples for biological markers and assessment of sexually transmitted infections (STIs). HIV-negative partners were counseled and tested for HIV-1. The study population mean age was 39.9 years, 53.6% were female, 62.5% were Caucasian, 52.6% had incomplete or complete elementary education, 63.1% resided in Porto Alegre. Demographic, behavioral and biological marker characteristics were similar between couples and single individuals. There was an association between adherence reported on ACASI and an undetectable serum viral load (P<0.0001). Logistic regression analysis demonstrated that single-tablet ARV-regimens were independe...Continue Reading

References

Jan 26, 2002·BMJ : British Medical Journal·Peter R Lamptey
Apr 7, 2007·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Tracey E WilsonStephen J Gange
Jul 9, 2008·Sexually Transmitted Diseases·Marineide Gonçalves MeloKarin Nielsen-Saines
Nov 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara HasseUNKNOWN Swiss HIV Cohort Study
Mar 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan A FiscusUNKNOWN A5185s Team
Jul 17, 2015·Open Forum Infectious Diseases·Roger D KouyosS Yerly
Jul 18, 2015·BMC Infectious Diseases·Sophie PattersonUNKNOWN CANOC collaboration
Jan 12, 2016·Journal of the International AIDS Society·Marie Suzan-MontiUNKNOWN ANRS-VESPA2 Study Group
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group
Jul 19, 2016·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team

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Citations

Jul 31, 2020·Cranio : the Journal of Craniomandibular Practice·Adriana A De StefanoGabriella Galluccio

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Methods Mentioned

BETA
PCR

Software Mentioned

Win PEPI
WinPepi
TasP

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