Oct 5, 2014

Antiretroviral interventions for preventing breast milk transmission of HIV

The Cochrane Database of Systematic Reviews
Angela B WhiteJennifer S Read

Abstract

An estimated 260,000 children under the age of 15 years acquired HIV infection in 2012. As much as 42% of mother-to-child transmission is related to breastfeeding. Antiretroviral prophylaxis for mothers or infants has the potential to prevent mother-to-child transmission of HIV through breast milk. To determine which antiretroviral prophylactic regimens are efficacious and safe for reducing mother-to-child transmission of HIV through breastfeeding and thereby avert child morbidity and mortality. Using Cochrane Collaboration search methods in conjunction with appropriate search terms, we identified relevant studies from January 1, 1994 to January 14, 2014 by searching databases including Cochrane CENTRAL, EMBASE and PubMed, LILACS, and Web of Science/Web of Social Science. Randomized controlled trials in which HIV-infected mothers breastfed their infants, and in which the mothers used antiretroviral prophylaxis while breastfeeding their children or their children received antiretroviral prophylaxis for at least four weeks while breastfeeding, were included. Abstracts of all trials identified were examined independently by two authors. We identified 15,922 references and examined 81 in detail. Data were abstracted independently u...Continue Reading

Mentioned in this Paper

Maternal-Fetal Infection Transmission
Pregnancy Complications, Infectious
Morbidity Aspects
Zidovudine
Lamivudine
HIV Infections
Controlled Clinical Trials, Randomized
Injection, Zidovudine,10 MG Administered
Breast Feeding
Milk, Human

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