Antiretroviral Non-Adherence is Associated With a Retrieval Profile of Deficits in Verbal Episodic Memory

The Clinical Neuropsychologist
Lisa C ObermeitHIV Neurobehavioral Research Program Group

Abstract

HIV-associated deficits in verbal episodic memory are commonly associated with antiretroviral non-adherence; however, the specific aspects of memory functioning (e.g., encoding, consolidation, or retrieval) that underlie this established relationship are not well understood. This study evaluated verbal memory profiles of 202 HIV+ participants who underwent a 30-day electronic monitoring of antiretroviral adherence. At the group level, non-adherence was significantly associated with lower scores on immediate and delayed passage recall and word list learning. Retention and recognition of passages and word lists were not related to adherence. Participants were then classified as having either a normal verbal memory profile, a "subcortical" retrieval profile (i.e., impaired free recall with relatively spared recognition), or a "cortical" encoding profile (e.g., cued recall intrusions) based on the Massman et al. ( 1990 ) algorithm for the California Verbal Learning Test. HIV+ participants with a classic retrieval deficit had significantly greater odds of being non-adherent than participants with a normal or encoding profile. These findings suggest that adherence to prescribed antiretroviral regimens may be particularly vulnerable t...Continue Reading

References

Sep 1, 1992·Journal of Clinical and Experimental Neuropsychology·P J MassmanJ C Gillin
Oct 1, 1990·Journal of Clinical and Experimental Neuropsychology·P J MassmanD P Salmon
Nov 1, 1990·American Pharmacy·G A HoltR Coyle
Apr 13, 2000·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·S L CatzT L McAuliffe
Mar 23, 2001·The Clinical Neuropsychologist·G TremontR A Stern
Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patricia García de OlallaJoan A Caylà
Oct 31, 2002·Journal of the International Neuropsychological Society : JINS·Kelly L LangeLeon J Thal
Feb 7, 2003·Journal of the International Neuropsychological Society : JINS·Shemira MurjiByron P Rourke
Aug 15, 2003·Journal of Clinical and Experimental Neuropsychology·Steven Paul WoodsDavid W Lovejoy
May 19, 2004·Journal of the International Neuropsychological Society : JINS·Robert K HeatonUNKNOWN HNRC Group
Oct 4, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Steven Paul WoodsUNKNOWN HIV Neurobehavioral Research Center (HNRC) Group
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maya L PetersenDavid R Bangsberg
Jan 9, 2009·Journal of the International Neuropsychological Society : JINS·Steven Paul WoodsUNKNOWN HIV NEUROBEHAVIORAL RESEARCH CENTER GROUP
Feb 18, 2009·Journal of Clinical and Experimental Neuropsychology·J Vincent FiloteoDouglas R Galasko
Mar 12, 2010·Neurology·Mark L EttenhoferCharles H Hinkin
Sep 29, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Matthew J WrightCharles H Hinkin
Oct 22, 2011·Journal of the International Neuropsychological Society : JINS·Erica WeberUNKNOWN HIV Neurobehavioral Research Program (HNRP) Group
Nov 8, 2013·American Journal of Alzheimer's Disease·Caitlin M DaimonBronwen Martin
Feb 14, 2014·American Journal of Alzheimer's Disease·Shanshan LiMei-Cheng Wang

❮ Previous
Next ❯

Citations

Mar 21, 2018·Journal of Clinical Psychology in Medical Settings·Erin E MorganUNKNOWN HIV Neurobehavioral Research Program (HNRP) Group
Sep 28, 2017·The Clinical Neuropsychologist·Gunes AvciSteven Paul Woods
Oct 30, 2019·Applied Neuropsychology. Adult·Pavel Y LitvinMatthew J Wright
Feb 19, 2020·Journal of the International Neuropsychological Society : JINS·Georgette D KanmogneRobert K Heaton
Oct 4, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kelli L SullivanSteven Paul Woods
Nov 15, 2016·Journal of Clinical and Experimental Neuropsychology·Michael K KeutmannEileen M Martin
May 1, 2017·AIDS and Behavior·Denise C VidotRaul Gonzalez
Feb 1, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Steven Paul WoodsErin E Morgan
Apr 1, 2021·Revista brasileira de enfermagem·Wenysson Noleto Dos SantosRichardson Augusto Rosendo da Silva

❮ Previous
Next ❯

Software Mentioned

MEMS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Ellen Woo, Maureen Schmitter-Edgecombe
© 2021 Meta ULC. All rights reserved