Antiretroviral Regimen Durability and Success in Treatment-Naive and Treatment-Experienced Patients by Year of Treatment Initiation, United States, 1996-2011

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Anandi N ShethFrank J Palella

Abstract

Although modern combination antiretroviral therapy (cART) regimens are better tolerated and less complex than earlier treatments, regimen modification or discontinuation remains a concern. We studied HIV Outpatient Study (HOPS) participants who initiated the first or second cART regimens during: 1996-1999, 2000-2003, 2004-2007, and 2008-2011. We analyzed regimen durability (time to regimen modification) and success (achieving undetectable plasma HIV RNA) for the first and second cART regimens using Kaplan-Meier curves and log-rank tests, and examined factors associated with durability and success of the first cART regimen using proportional hazards models. Durability of cART was progressively longer for cART regimens initiated in more recent periods: median first cART regimen durations were 1.0, 1.1, 2.1, and 4.6 years in 1996-1999, 2000-2003, 2004-2007, and 2008-2011, and the median second cART durations were 0.9, 1.2, 2.8, and 3.9 years, respectively (both P < 0.001). Comparing 1996-1999 and 2008-2011, the percentage of patients who achieved an undetectable HIV RNA within 6 months of first cART initiation increased from 65% to 81% and from 63% to 80% on second cART (both P < 0.001). Among patients initiating first cART during...Continue Reading

References

Aug 13, 2002·AIDS·Frank J PalellaUNKNOWN HIV Outpatient Study Investigators
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ray Y ChenMichael S Saag
Jun 10, 2010·PloS One·Carina CesarUNKNOWN Caribbean, Central and South America Network for HIV Research (CCASAnet) Collaboration of the International Epidemiologic Da
Sep 14, 2010·Journal of Internal Medicine·A Mackinnon
Jan 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laurence SlamaUNKNOWN Multicenter AIDS cohort Study

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Citations

Jun 20, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Thibaut Davy-MendezSonia Napravnik
Jun 30, 2018·AIDS·Maria C B MendozaUNKNOWN HIV Outpatient Study Investigators
Jun 27, 2018·Open Forum Infectious Diseases·Jonathan ColasantiMohammed K Ali
Apr 19, 2016·AIDS·Ellen F EatonMeredith L Kilgore
Aug 20, 2019·Journal of the International AIDS Society·Yann RuffieuxUNKNOWN Swiss HIV Cohort Study and the Swiss National Cohort
May 27, 2020·Open Forum Infectious Diseases·Kate BuchaczUNKNOWN HIV Outpatient Study (HOPS) Investigators
Oct 16, 2020·AIDS·Kristina L BajemaUNKNOWN Centers for AIDS Research Clinical Network of Integrated Systems (CNICS)
May 26, 2021·AIDS Research and Human Retroviruses·Stockton MayerUNKNOWN HIV Outpatient Study Investigators

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