Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis

BMC Infectious Diseases
Maha A Al-MozainiAbdulrahman A Alrajhi

Abstract

Since the early 90's antiretroviral drugs have been available at King Faisal Specialist Hospital and Research Centre (KFSH&RC), a referral hospital in Riyadh, Saudi Arabia, for the treatment of both adults and children infected with HIV-1. However, up to date, there are no genetic profiling data for the resistance-causing mutations in HIV-1 virus in patients on antiretroviral drugs therapy. This paper presents an initial report and a profiling survey of drug resistance-associated mutations of 103 HIV-1 patients seen at KFSH&RC. This is a retrospective study on Patients treated at KFSH&RC since 2003 up to 2016. The analysis was done on the drug resistance mutations profiles of 103 patients who were undergoing highly active antiretroviral therapy protocols. Our analysis shows that the drug resistance mutations reported in our treatment cohort of HIV-infected adults patients is similar what is internationally reported to some extent. Additionally, we have identified novel drug resistance causing mutations. Furthermore, different profile of drug resistance causing mutations was also observed. Patients showed both similar and new drug resistant causing mutations, early identification of these mutations is crucial to guide and avoid ...Continue Reading

References

Jan 14, 2000·JAMA : the Journal of the American Medical Association·D V HavlirD D Richman
Mar 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S G Deeks
May 24, 2001·Journal of Molecular Biology·Y HsiouE Arnold
Apr 5, 2002·Clinical Microbiology Reviews·Robert W Shafer
Feb 5, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C SuñéT Klimkait
Jan 6, 2005·The Journal of Infectious Diseases·P Richard HarriganJulio S G Montaner
Nov 5, 2005·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Unaí TupinambásDirceu Greco
Aug 4, 2007·Antiviral Research·Jorge L Martinez-Cajas, Mark A Wainberg
Jul 22, 2009·Annals of Internal Medicine·Frank J PalellaUNKNOWN HOPS (HIV Outpatient Study) Investigators
Nov 29, 2011·Fundamental & Clinical Pharmacology·Palanee Ammaranond, Sayompoo Sanguansittianan
Jul 12, 2013·ISRN Microbiology·Maria Mercedes Santoro, Carlo Federico Perno
Apr 22, 2015·The Pediatric Infectious Disease Journal·Maurizio de MartinoElena Chiappini
Sep 1, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Antoinette G NelsonPatrick J Sinko
Sep 2, 2015·Current Topics in Medicinal Chemistry·Michael RochePaul R Gorry
Sep 29, 2015·International Journal of Clinical Pharmacology and Therapeutics·Gisèle Kouakou-SiransyHenri Die Kakou
Oct 31, 2015·Future Microbiology·Nicolas Sluis-CremerRaymond F Schinazi
Nov 1, 2015·Indian Pediatrics·Subramani SeenivasanSoumya Swaminathan

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