Antiretroviral therapeutic possibilities for human immunodeficiency virus/acquired immunodeficiency syndrome

Pharmacology & Therapeutics
G A Balint

Abstract

In human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) illness, the reverse transcriptase and protease (PRT) enzymes of HIV are currently the targets of antiretroviral (ARV) therapy. Nucleoside analogues were the first group of ARV drugs that exerted antiviral activity in patients. More recently, PRT inhibitors have provided new approaches in the treatment of HIV infection and AIDS. Impressive clinical results have been obtained with combination therapies of three ARV drugs, including one PRT inhibitor. It is worth mentioning also that apart from these two main drug groups, there are many new compounds under development, including a vaccine(s) against HIV.

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Citations

Nov 30, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B Macchi, A Mastino
Jun 12, 2013·Journal of Pharmaceutical Sciences·Kelen C C SoaresJennifer Dressman
Jan 23, 2013·Journal of Pharmacological and Toxicological Methods·André Bersani DezaniCristina Helena Dos Reis Serra
Mar 24, 2012·Drug Development and Industrial Pharmacy·Jucimary V SantosLuís A E Batista de Carvalho
Feb 6, 2010·Journal of Biochemical and Molecular Toxicology·Soghra Khatun HaqRizwan Hasan Khan

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