Antiretroviral therapy during tuberculosis treatment and marked reduction in death rate of HIV-infected patients, Thailand.

Emerging Infectious Diseases
Somsak AkksilpJay K Varma

Abstract

Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand.

References

Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M ElliottP Nunn
Apr 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D J MartinK Keddy
Feb 3, 1998·International Journal of Epidemiology·L M YuT Marshall
Jul 31, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S TansuphasawadikulT D Mastro
Apr 20, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanJ L Jones
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Oct 13, 2004·The Journal of Infectious Diseases·Keertan DhedaMarc C Lipman
Aug 20, 2005·American Journal of Respiratory and Critical Care Medicine·William BurmanUNKNOWN Tuberculosis Trials Consortium
Feb 2, 2006·American Journal of Public Health·Nicholas FreudenbergAndrew Greenberg
Apr 19, 2006·The Journal of Infectious Diseases·Ronan A M BreenM C I Lipman
Aug 4, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Weerawat ManosuthiSomnuek Sungkanuparph

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Citations

Oct 22, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Wanitchaya KittikraisakJay K Varma
Feb 26, 2010·The New England Journal of Medicine·Kevin P CainJay K Varma
Dec 17, 2009·AIDS Research and Human Retroviruses·Humphrey J ShaoNathan M Thielman
Oct 7, 2009·AIDS Patient Care and STDs·L Beth GadkowskiJason E Stout
Jan 5, 2010·Current Opinion in HIV and AIDS·Karen Cohen, Graeme Meintjes
Feb 15, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Keren MiddelkoopRobin Wood
Sep 26, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andrew P SteenhoffRobert Gross
Sep 5, 2008·PloS One·Amornrat AnuwatnonthakateJay K Varma
Oct 17, 2012·HIV/AIDS : Research and Palliative Care·Pacharee KantipongNorio Yamada
Jun 30, 2011·Drugs·Kartik K VenkateshKenneth H Mayer
Feb 6, 2009·Emerging Infectious Diseases·Kevin P CainJay K Varma
Oct 25, 2012·Emerging Infectious Diseases·Suchunya AungkulanonKanitta Bundhamcharoen
Aug 13, 2011·Bulletin of the World Health Organization·Philippe GlaziouMario Raviglione
Dec 22, 2014·BMC Infectious Diseases·Nigel FieldPam Sonnenberg
Jul 3, 2013·The Medical Clinics of North America·John B Lynch
Sep 9, 2009·Tropical Medicine & International Health : TM & IH·Waraya AmnuaiphonJay K Varma
Aug 30, 2008·Tropical Medicine & International Health : TM & IH·Patjuban HemhongsaJay K Varma
Apr 25, 2015·AIDS Research and Therapy·Weerawat ManosuthiUNKNOWN Adults and Adolescents Committee of the Thai National HIV Guidelines Working Group
Feb 7, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nara KingkaewJay K Varma
Oct 7, 2016·AIDS Research and Therapy·Narendran GopalanSrikanth Tripathy
Jul 19, 2012·International Journal of STD & AIDS·S LimmahakhunK Supparatpinyo
May 18, 2012·Asia-Pacific Journal of Public Health·Wannak SamrithJunichi Sakamoto
Jun 25, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Delphine SculierJay K Varma
Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Neel R GandhiUNKNOWN Tugela Ferry Care and Research (TFCaRes) Collaboration
Jun 18, 2009·Current Opinion in HIV and AIDS·Stephen D Lawn, Gavin Churchyard
Jul 1, 2010·Expert Review of Anti-infective Therapy·Eric Leibert, William N Rom
May 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Weerawat ManosuthiUNKNOWN TIME Study Team

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