DOI: 10.1101/477158Nov 23, 2018Paper

Antiretroviral therapy is the principal cause of tuberculosis decline in southern and eastern Africa

BioRxiv : the Preprint Server for Biology
Chris Dye, Brian G Williams

Abstract

The incidence of tuberculosis (TB) in southern and eastern Africa was driven sharply upwards during 1980s and 1990s by coinfection with Mycobacterium tuberculosis and the human immunodeficiency virus (HIV). Although drug treatments for TB infection (isoniazid preventive therapy) and disease (combinations of TB drugs) can reduce TB incidence if implemented effectively, we find that antiretroviral therapy (ART) for HIV infection was the principal cause of TB decline in 12 of the worst affected African countries between 2003 and 2016. ART prevented up to 1.92 million HIV-positive TB cases, or 17.3 percent of the total number expected. In these 12 countries, over the period 2003-16, ART made the most significant contribution towards achieving international targets for the reduction of TB incidence.

Related Concepts

Pharmacotherapy
HIV
HIV Infections
Isoniazid
Mycobacterium tuberculosis
Tuberculosis
Prophylactic Treatment
Coinfection
Immunodeficiency virus
Pharmacologic Substance

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
Lorenzo GuglielmettiSandro Vento
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
D M GrayH J Zar
Lancet
Lori Elizabeth Dodd, Robert J Wilkinson
© 2021 Meta ULC. All rights reserved