Antiretroviral Treatment and Resistance Patterns in HIV-Infected Children

Current Infectious Disease Reports
Olatunji AdetokunbohMojisola Oluwasanu

Abstract

Paediatric HIV-infected patients have higher risk of developing resistance to antiretroviral drugs, and from public health perspective, drug resistance remains a limiting factor for effective management of HIV infection in children. We reviewed the current evidences available on the antiretroviral treatment and resistance patterns in HIV-infected children. Prevalence of HIV drug resistance varied among the three main classes of antiretroviral drugs, namely nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors in both treatment naïve and treatment-experienced children in different countries. Most of the patients with extensive triple-class drug-resistant mutations were found to be considerably exposed to the three main classes of antiretroviral agents. Identification of genetic factors linked with susceptibility to perinatal transmission of HIV may be key in understanding the development of resistance due to waning antiviral effectiveness. Children who were less likely to achieve viral re-suppression were more likely to have resistance mutations. Newer drugs such as etravirine can be used as alternatives in case of resistance to efavirenz while newly developed diagno...Continue Reading

References

Mar 5, 2004·The New England Journal of Medicine·François Clavel, Allan J Hance
Aug 5, 2008·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA
Oct 8, 2009·Antiviral Research·Roger Paredes, Bonaventura Clotet
Apr 10, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gonzague JourdainUNKNOWN Program for HIV Prevention and Treatment (PHPT) Study Group
Nov 29, 2011·Fundamental & Clinical Pharmacology·Palanee Ammaranond, Sayompoo Sanguansittianan
Feb 15, 2012·The Pediatric Infectious Disease Journal·Verónica BrizMa Ángeles Muñoz-Fernández
Mar 22, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew P FoxUNKNOWN IeDEA-SA collaboration
Jul 13, 2012·The Pediatric Infectious Disease Journal·Miguel de MulderAfrica Holguin
Oct 20, 2012·Journal of the International AIDS Society·Teri RobertsNathan Ford
Feb 12, 2013·Bulletin of the World Health Organization·Peter BarronAmeena Goga
Jan 7, 2014·AIDS Research and Human Retroviruses·Mukesh KumarRamesh S Paranjape
Apr 15, 2014·Journal of Infection in Developing Countries·Fatima MirAnita Kaniz Mehdi Zaidi
Apr 15, 2014·The Journal of Antimicrobial Chemotherapy·Elichilia R ShaoMax Essex
May 3, 2014·The Journal of Antimicrobial Chemotherapy·Patricia Rojas Sánchez, Africa Holguín
Aug 21, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rachel C VreemanTerry F Blaschke
Aug 28, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Diana F ClarkeUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1097 Study Team
Aug 31, 2014·AIDS Research and Human Retroviruses·Rency LelSamoel Khamadi
Nov 15, 2014·Journal of the International AIDS Society·Ezequiel CordovaClaudia Rodriguez
Dec 30, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Randall G FisherGert U Van Zyl
Feb 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Rojas SánchezUNKNOWN Madrid Cohort of HIV-Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Netw
Mar 7, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Horacio A DuarteUNKNOWN NISDI PLACES Study Group
Dec 1, 2013·Journal of the Pediatric Infectious Diseases Society·Dimitri Van der LindenValérie Lamarre

❮ Previous
Next ❯

Citations

Feb 20, 2020·The Journal of Antimicrobial Chemotherapy·Josephine BriceSidonie Lambert-Niclot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.