Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.

AIDS
Eugène MessouCatherine Seyler

Abstract

To determine the rates and causes of first antiretroviral treatment changes in HIV-infected adults in Côte d'Ivoire. We evaluated adults who initiated antiretroviral treatment in an outpatient clinic in Abidjan. We recorded baseline and follow-up data, including drug prescriptions and reasons for changing to alternative first-line regimens (drug substitution for any reason but failure) or second-line regimens (switch for failure). Two thousand and twelve HIV-infected adults (73% women) initiated antiretroviral treatment. At baseline, 9% of all patients were on treatment for tuberculosis and 3% of women were pregnant. First-line antiretroviral treatment consisted of two nucleoside reverse transcriptase inhibitors (58% stavudine-lamivudine, 42% zidovudine-lamivudine) and efavirenz (63%), nevirapine (32%) or indinavir (5%). Median follow-up time was 16.9 months. During this time, 205 (10%) patients died and 261 (13%) were lost to follow-up. Overall, the rate of treatment modifications was 20.7/100 patient-years. The most common modifications were drug substitutions for intolerance (12.4/100 patient-years), pregnancy (4.5/100 patient-years) and tuberculosis (2.5/100 patient-years). The rates of intolerance-related substitutions wer...Continue Reading

References

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Citations

Sep 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Eugène MessouXavier Anglaret
Sep 5, 2012·Journal of the International AIDS Society·Serge-Paul EholiéXavier Anglaret
Mar 7, 2012·North American Journal of Medical Sciences·Beharu Woldemedhin, Nasir Tajure Wabe
Jul 8, 2011·Pharmacoepidemiology and Drug Safety·Antoine JaquetUNKNOWN IeDEA West Africa Collaboration

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