PMID: 6985371Mar 1, 1982Paper

Antirheumatic drugs and macrophage function: effects on tumour cell growth in vitro

Clinical Rheumatology
L BinderupE Arrigoni-Martelli

Abstract

The ability of the antirheumatic drugs D-penicillamine, chloroquine and levamisole to modify macrophage-mediated inhibition of tumour cell growth in vitro was investigated. Increasing numbers of rat peritoneal macrophages were cocultured with a fixed number of ascites hepatoma AH-13 rat tumour cells. Tumour cell growth was assessed as the uptake of 3H-thymidine (3H-TdR) by AH-13 cells at the end of a 24 h period of coculture with macrophages treated in vitro or in vivo with the various drugs. In vitro, preincubation of macrophages with D-penicillamine or chloroquine (50 - 250 micrograms/ml) increased tumour cell 3H-TdR incorporation, compared to cultures with untreated macrophages. Macrophages from rats treated with D-penicillamine or chloroquine (50 mg/kg/day orally) for 4 days similarly increased tumour cell 3H-TdR incorporation, compared to cultures with macrophages from untreated rats. These effects persisted for at least 3 to 4 weeks of treatment. Preincubation with levamisole (10 - 100 micrograms/ml) in vitro had no effect on macrophage-mediated inhibition of tumour cells, whereas increased tumour cell 3H-TdR incorporation was observed in cultures with macrophages from rats treated with levamisole (5 mg/kg/day orally) in ...Continue Reading

References

Dec 1, 1979·The American Journal of Medicine·S A Paget, A Gibofsky
Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·A MantovaniR B Herberman
Jan 1, 1979·Biochemical Pharmacology·L Binderup, E Arrigoni-Martelli
Apr 1, 1978·Scandinavian Journal of Immunology·L BinderupE Arrigoni-Martelli
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Sep 1, 1980·Biochemical Pharmacology·L BinderupE Arrigoni-Martelli
Jan 1, 1982·International Journal of Immunopharmacology·L BinderupE Arrigoni-Martelli
Jan 1, 1981·International Journal of Immunopharmacology·D J Cameron, W H Churchill
Jan 1, 1980·Scandinavian Journal of Immunology·L BinderupE Arrigoni-Martelli
Feb 1, 1964·Arthritis and Rheumatism·C M PEARSON

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·D A Joyce

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