Antirheumatic drugs in older adults and polypharmacy issues.

Zeitschrift für Gerontologie und Geriatrie
Ilke Coskun Benlidayi, Yesim Gokce Kutsal

Abstract

Older individuals experience various noninflammatory and autoimmune inflammatory rheumatic diseases. Given the increased incidence of rheumatic conditions in older adults, it is of great importance for healthcare providers to be aware of the potential benefits and risks of antirheumatic drugs. The present article aims to provide a comprehensive review regarding antirheumatic drug use in older patients, particularly by focusing on safety issues and polypharmacy. Antirheumatic medications include nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and disease-modifying antirheumatic drugs (DMARDs), which comprise conventional synthetic DMARDs, targeted synthetic DMARDs and biological DMARDs. Due to the alteration in drug pharmacokinetics and pharmacodynamics in old people, antirheumatic drug efficiency and safety may be different than in the younger population. Polypharmacy and multimorbidity are other potential challenges to be faced during the treatment of older patients with rheumatic diseases. The current review also discusses the strategies to minimize adverse reactions due to antirheumatic drugs.

References

Jul 2, 2003·Drugs & Aging·Alberto PilottoUNKNOWN Geriatric Gastroenterology Study Group (Societè Italiana Gerontologie Geriatria)
Sep 1, 2009·Journal of the American Medical Directors Association·Yesim Gokce KutsalAynur Basaran
Oct 16, 2012·Pharmacoepidemiology and Drug Safety·Lisa J HerrintonJames D Lewis
Sep 27, 2015·European Journal of Clinical Pharmacology·Eline TommeleinKoen Boussery
Feb 19, 2017·Research in Social & Administrative Pharmacy : RSAP·Barbara FarrellJames Conklin
Feb 3, 2018·Aging and Disease·Supakanya WongrakpanichJanani Rangaswami
Jul 10, 2018·Rheumatology·Clément LahayeMartin Soubrier
Sep 23, 2018·Research in Social & Administrative Pharmacy : RSAP·James ConklinSalima Suleman
Jan 30, 2019·Journal of the American Geriatrics Society·UNKNOWN By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel
Feb 28, 2019·Rheumatology International·Ilke Coskun Benlidayi
Jun 12, 2020·Rheumatology International·Ilke Coskun Benlidayi

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