Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus.

Arthritis and Rheumatism
E BonfaK Elkon

Abstract

Autoantibodies directed against a ribosomal small subunit protein of 20,000 molecular weight were found in sera from 5 of 44 patients with systemic lupus erythematosus (11%) and 5 of 48 MRL/lpr mice (10%). This ribosomal protein was identified as S10 on the basis of two-dimensional gel electrophoresis and immunoblotting, as well as immunoblots of the purified S10 protein. The S10 protein antigen was readily extracted from ribosomes at low salt (300 mM KCl) and low magnesium (0.5 mM) concentrations, consistent with the highly exposed location proposed for this protein on the 40S subunit. Anti-S10 antibodies were observed significantly more frequently in lupus sera containing both anti-Sm and antiribosomal P protein antibodies and in MRL/lpr sera with anti-Sm activity, suggesting a linked pattern of autoantibody response. Together with anti-Sm and antiribosomal P protein antibodies, anti-S10 represents a third autoantibody highly specific for lupus in humans and MLR/lpr mice.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I EmanuilovC Freienstein
Feb 1, 1978·The Journal of Experimental Medicine·R A EisenbergF J Dixon
Jan 1, 1979·Annual Review of Biochemistry·I G Wool
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 1, 1976·Molecular Biology Reports·R ReyesD Vazquez
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W MöllerD Richter
Aug 1, 1985·The Journal of Experimental Medicine·K B ElkonC L Foster
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K ElkonN Brot
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K ElkonN Brot
Mar 1, 1988·The Journal of Cell Biology·J A SteitzT Yario
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T UchiumiR R Traut
Jun 1, 1987·The Journal of Experimental Medicine·D M Klinman, A D Steinberg
Aug 1, 1986·Arthritis and Rheumatism·E Bonfa, K B Elkon
May 1, 1986·The Journal of Experimental Medicine·C C BunnM B Mathews
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H M FurneauxJ Hurwitz
Jan 1, 1985·Advances in Immunology·A N Theofilopoulos, F J Dixon
Jan 1, 1971·The Journal of Experimental Medicine·R C MellorsK Krawczynski
Mar 1, 1970·European Journal of Biochemistry·J C Clegg, H R Arnstein
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·G Blobel, D Sabatini
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J A SteitzE Gottlieb
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Apr 1, 1965·Arthritis and Rheumatism·B C STURGILL, R R CARPENTER

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Citations

Apr 12, 2007·Clinical Reviews in Allergy & Immunology·Emese Kiss, Yehuda Shoenfeld
Jul 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·J C MonierJ P Bringuier
Jul 1, 1997·Clinical Imaging·S EharaT Satoh
Jun 1, 1989·European Journal of Biochemistry·A GlückI G Wool
Jun 1, 1991·Immunological Reviews·J Winfield, W Jarjour
Aug 18, 1999·Immunological Reviews·O T ChanM J Shlomchik
Apr 5, 2005·Autoimmunity·Roberto Gerli, Laura Caponi
Apr 1, 1995·Seminars in Arthritis and Rheumatism·C A von Mühlen, E M Tan
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Feb 13, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C J AndersonH A Stafford
Jul 13, 2000·Cell Death and Differentiation·W G DegenW J van Venrooij
Oct 30, 1990·Biochemical and Biophysical Research Communications·T SatoM Arakawa

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