Antisaccade performance in biological relatives of schizophrenia patients: a meta-analysis

Schizophrenia Research
D L LevyN R Mendell

Abstract

Poor performance on the antisaccade (AS) task has been interpreted as a potential indicator of genetic liability that may enhance the power of linkage studies of a multidimensional phenotype for schizophrenia. Every study has replicated the finding of significantly worse performance in schizophrenia patients regardless of which specific antisaccade paradigm was employed. In some studies involving a standard version of the antisaccade task, relatives of schizophrenia patients made an increased number of errors, but in other studies that used this same paradigm, relatives of schizophrenia patients did not differ from controls. In this paper, we report the results of a meta-analysis on studies that used the standard antisaccade paradigm. The meta-analysis shows that those studies that reported large effect sizes and statistically significant differences between relatives of schizophrenia patients and controls used inclusion/exclusion criteria that were not symmetrical between the two groups, whereas those studies that reported small and nonsignificant differences between relatives of schizophrenia patients and controls used symmetrical inclusion/exclusion criteria. Specifically, studies that applied stricter psychopathology exclus...Continue Reading

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Citations

Dec 1, 2006·Schizophrenia Bulletin·Bruce I TuretskyNeal R Swerdlow
May 2, 2008·Schizophrenia Bulletin·S Kristian HillJohn A Sweeney
Dec 7, 2007·Experimental Brain Research·Jason J S BartonDara S Manoach
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