Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

PLoS Neglected Tropical Diseases
Julien PortelaAnne Robert

Abstract

Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action, not only the alkylation of heme. The synergy observed with praziquantel on infected mice is in favor of the development of these trioxaquines as potential anti-schistosomal agents.

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Methods Mentioned

BETA
Scanning electron microscopy
X-ray
electron microscopy
Transmission
transmission-electron microscopy

Software Mentioned

imageJ

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