Antischistosomal drugs: past, present ... and future?

Pharmacology & Therapeutics
Donato CioliS Archer


The major antischistosomal drugs that have been or still are in use against infections with schistosomes are considered here together with some compounds that have not been in clinical use, but show interesting characteristics. Each individual compound presents aspects that may be enlightening about parasite biochemistry, parasite biology, and host-parasite relationships. Special attention is given to the mechanisms of action, an understanding of which is seen here as a major factor of progress in chemotherapy. Three compounds are currently in use, i.e., metrifonate, oxamniquine, and praziquantel, and all three are included in the World Health Organization list of essential drugs. They are analyzed in some detail, as each one presents advantages and disadvantages in antischistosomal therapy. The reported occurrence of drug-resistant schistosomes after treatment with oxamniquine and praziquantel suggests strict monitoring of such phenomena and encourages renewed efforts toward the development of multiple drugs against this human parasite.


Jan 1, 1976·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·N R Gear
Jan 1, 1977·Advances in Pharmacology and Chemotherapy·N Katz
Oct 15, 1975·Biochemical Pharmacology·G R Hillman, W B Gibler
Nov 1, 1975·Journal of Toxicology and Environmental Health·T Ong, F J de Serres
Nov 9, 1979·Science·F A SchanneJ L Farber
Jul 21, 1977·Zeitschrift Für Parasitenkunde·R Gönnert, P Andrews
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·H W Diekmann
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·J Pütter
Aug 1, 1977·Parasitology·N M Woolhouse, B Kaye
Oct 13, 1978·Archives of Toxicology·I NordgrenM Sandoz
Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·O BulayP Shubik
Aug 1, 1976·International Journal for Parasitology·D Cioli
Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·R CamposL C Da Silva
Nov 11, 1975·Journal of Toxicology and Environmental Health·V A RayM L Hyneck
Jun 8, 1975·The New England Journal of Medicine·L T WebsterK S Warren
Nov 1, 1975·Journal of Toxicology and Environmental Health·W L Russell
Nov 1, 1975·Journal of Toxicology and Environmental Health·S M Sieber, R H Adamson
Nov 1, 1975·Cancer Letters·H K UrmanP Shubik
Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
May 1, 1992·Neurochemical Research·N OganeE Messamore
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P J BrindleyA Sher
Jan 1, 1991·Revista Do Instituto De Medicina Tropical De São Paulo·P M Coelho, L H Pereira
Feb 1, 1991·Pharmacology & Toxicology·Y A Abdi, T Villén
Mar 1, 1991·Molecular and Biochemical Parasitology·F Eshete, J L Bennett

❮ Previous
Next ❯


Apr 26, 2006·Parasitology Research·Gabriela Ribeiro-dos-SantosLuciana C C Leite
Mar 4, 2009·Parasitology Research·Rashad Abdul-GhaniAzza Hassan
Jul 9, 2011·Parasitology Research·Priscilla P LuzMarcio L Andrade E Silva
Jul 27, 2001·Current Gastroenterology Reports·T W Schafer, B R Hale
Feb 15, 2001·Current Infectious Disease Reports·G. Richard Olds, Srinivasan Dasarathy
Aug 1, 1996·Parasitology Today·P G FallonJ L Bennett
Jan 1, 1996·Parasitology Today·C A RedmanR J Martin
Apr 7, 2005·Molecular and Biochemical Parasitology·Geoffrey N BentleyAlison Agnew
Mar 5, 2003·Experimental Parasitology·Shu-Hua XiaoJürg Utzinger
Jun 13, 2001·International Journal for Parasitology·P Köhler
Dec 4, 2001·International Journal for Parasitology·J UtzingerM Tanner
Jan 24, 2004·Lancet·Donato Cioli, Piero Liberti
Oct 17, 2006·Parasitology Today·D Cioli
May 14, 1999·Parasitology Today·N C Sangster, J Gill
Aug 26, 1999·Parasitology Today·J Kusel, P Hagan
Apr 4, 2003·International Journal of Pharmaceutics·Alan L de MeloFrédéric Frézard
Aug 8, 2001·Journal of Pharmaceutical and Biomedical Analysis·H Meier, G Blaschke
Jun 1, 1997·Journal of Helminthology·J Barrett
Jan 1, 1996·Parasitology·N Sangster
Apr 13, 2007·Parasitology·F AngelucciC Valle
Aug 21, 2009·Parasitology·Paul Hagan
Sep 26, 2012·Journal of Medicinal Chemistry·Malay PatraGilles Gasser
Jan 22, 2009·Médecine sciences : M/S·Colette DissousThavy Long
Jul 31, 2008·Assay and Drug Development Technologies·Wendy A LeaAnton Simeonov
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Jürg UtzingerBurton H Singer
Feb 7, 2001·Clinical Microbiology Reviews·S Geerts, B Gryseels
Jan 29, 2011·Journal of Clinical Microbiology·Theresia ManneckJennifer Keiser
Feb 1, 2008·PLoS Neglected Tropical Diseases·Anton SimeonovChristopher P Austin
Aug 13, 2013·PLoS Neglected Tropical Diseases·Steffen HahnelThomas Quack
Dec 25, 2013·PLoS Neglected Tropical Diseases·Regina CoeliGuilherme Oliveira
Dec 24, 2010·Malawi Medical Journal : the Journal of Medical Association of Malawi·Takafira MduluzaPatricia D Ndhlovu
Dec 20, 2008·Parasitology Research·Lizandra G MagalhãesVanderlei Rodrigues
Oct 19, 2011·Parasitology Research·Lizandra G MagalhãesMárcio L A e Silva
Sep 10, 2014·Phytochemistry·Márcio Luis Andrade e SilvaJairo Kenupp Bastos
Sep 15, 2010·Toxicology Letters·Naira R MacielAndrea Grabe-Guimarães
Aug 13, 2008·Experimental Parasitology·Marina Clare VinaudJosé Clecildo Barreto Bezerra

❮ Previous
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